Related Publications
Publications related to small vessel disease
2020
March
Lazic et al (2020) Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease Link
Olama et al. (2020) Simple MRI score aids prediction of dementia in cerebral small vessel disease. Link
He et al. (2020) Homozygous NOTCH3 p.R587C mutation in Chinese patients with CADASIL: a case report. Link
February
Wang et al. (2020) Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease. Link
Robalo et al. (2020) Effect of fixed-density thresholding on structural brain networks: a demonstration in cerebral small vessel disease. Link
van Veluw et al. (2020) Editorial: Cerebral Small Vessel Diseases: From Vessel Alterations to Cortical Parenchymal Injury Link
Contreras et al (2020) Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers Link
Hauglund et al. (2020). Meningeal lymphangiogenesis and enhanced glymphatic activity in mice with chronically implanted EEG electrodes Link
Hussein et al. (2020). The association between resting‐state functional magnetic resonance imaging and aortic pulse‐wave velocity in healthy adults. Link
Garnier-Crussard et al. (2020) White matter hyper-intensities in ageing: Pathophysiology, associated cognitive disorders and prevention Link
Vernooij & Buchem (2020) Neuroimaging in Dementia. Link
Yuan et al. (2020) Single nucleotide polymorphism of MTHFR rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease. Link
Liu et al. (2020) Fiber Connectivity Density in Cerebral Small-Vessel Disease Patients With Mild Cognitive Impairment and Cerebral Small-Vessel Disease Patients With Normal Cognition. Link
Yatawara et al. (2020) The role of cerebral microbleeds in the incidence of post-stroke dementia. Link
Suzuyama et al. (2020) Total small vessel disease score and cerebro-cardiovascular events in healthy adults: The Kashima scan study. Link
January
Lemmens et al. (2020) Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker. Link
Dawe et al. (2020) Late-life cognitive decline is associated with hippocampal volume, above and beyond its associations with traditional neuropathologic indices Link
Zhai et al.(2020) Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling Pathway Link
Caldwell et al. (2020) Evidence for temperature-mediated regional increases in cerebral blood flow during exercise Link
Holmsquist et al. (2020) The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016 Link
Wouts et al. (2020) Empirical support for the vascular apathy hypothesis: A structured review Link
Zhu et al. (2020) Reduced Levels of Cerebrospinal Fluid/Plasma Aβ40 as an Early Biomarker for Cerebral Amyloid Angiopathy in RTg-DI Rats Link
Ge et al. (2020) Analysis of young ischemic stroke patients in northeast China. Link
2019
December
Zhou et al. (2019) Irregular surface of carotid atherosclerotic plaque is associated with ischemic stroke: a magnetic resonance imaging study Link
Xu et al. (2019) Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis Link
November
Fultz et. al. (2019) Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep Link
Grifin el.al. (2019) Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Link
Liang et.al. (2019) Cerebral Small Vessel Disease Burden Is Associated With Accelerated Poststroke Cognitive Decline: A 1-Year Follow-Up Study. Link
Lo et. al. (2019) Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups. Link
Qu et.al. (2019) Preexisting Cerebral Abnormalities and Functional Outcomes After Acute Ischemic Stroke. Link
Wang et.al. (2019) Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study. Link
Huang et. al. (2019) Association of obstructive sleep apnea and cerebral small vessel disease: a systematic review and meta-analysis Link
October
Chung et al (2019) Genome-wide association study of cerebral small vessel disease reveals established and novel loci. Link
Denver et. al. (2019) A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer’s Disease Link
Dobrynina et.al. (2019) Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease. Link
Goldstein et.al. (2019) Cerebral Small Vessel Disease Burden and All-Cause Mortality: Mayo Clinic Florida Familial Cerebrovascular Diseases Registry. Link
Raz et.al. (2019) Possible Empirical Evidence of Glymphatic System on CT after Endovascular Perforations. Link
Villeneuve S (2019) Lifespan Cognitive Reserve—A Secret to Coping With Neurodegenerative Pathology. Link
Neves et al. (2020) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL
September
Brutto et.al. (2019) Effect of Heart Rate Variability on the Association Between the Apnea-Hypopnea Index and Cerebral Small Vessel Disease. Link
Duperron et.al. (2019) High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage. Link
Faraco et.al. (2019) Dietary salt promotes cognitive impairment through tau phosphorylation. PDF
August
Hernández-Díaz et.al. (2019) Cerebral Small Vessel Disease Associated with Subclinical Vascular Damage Indicators in Asymptomatic Hypertensive Patients. Link
Huo et. al. (2019) Total Small Vessel Disease Burden Predicts Functional Outcome in Patients With Acute Ischemic Stroke. Link
Kubota et.al. (2019) Association Between Cerebral Small Vessel Disease and Central Motor Conduction Time in Patients with Vascular Risk. Link
Gutierrez at.al. (2019) Brain arterial dilatation modifies the association between extracranial pulsatile hemodynamics and brain perivascular spaces: the Northern Manhattan Study. Link
Low et.al. (2019) Inflammation and cerebral small vessel disease: A systematic review. Link
Park et.al. (2019) MRI Assessment of Cerebral Small Vessel Disease in Patients with Spontaneous Intracerebral Hemorrhage. Link
Reginold et al. (2019) The efficiency of the brain connectome is associated with cerebrovascular reactivity in persons with white matter hyperintensities. Link
Roth et.al. (2019) Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke. Link
Shreiber et.al. (2019) Invited Review: The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies. Link
Sorond & Gorelick (2019) Brain White Matter: A Substrate for Resilience and a Substance for Subcortical Small Vessel Disease. Link
Wang et.al. (2019) Enlarged Perivascular Spaces and Cerebral Small Vessel Disease in Spontaneous Intracerebral Hemorrhage Patients. Link
Weber et al. (2019) Age and Sex Differences in Ischemic Stroke Treatment in a Nationwide Analysis of 1.11 Million Hospitalized Cases. Link
Wo et.al. (2019) Plasma Klotho concentration is associated with the presence, burden and progression of cerebral small vessel disease in patients with acute ischaemic stroke. Link
Elkin et al. (2019) GlymphVIS: Visualizing Glymphatic Transport Pathways Using Regularized Optimal Transport. Link
July
Brutto et.al. (2019) Neuroimaging signatures of cerebral small vessel disease and risk of falls in stroke-free older adults living in rural Ecuador. The Atahualpa Project. Link
Cheng et.al. (2019) Alcohol promotes waste clearance in the CNS via brain vascular reactivity. PDF
Coutts et al. (2019) Rate and Prognosis of Brain Ischemia in Patients With Lower-Risk Transient or Persistent Minor Neurologic Events. Link
Iadecola et. al. (2019) Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel. Link
Pétrault et.al. (2019) Cerebral microbleeds: Beyond the macroscope. Link
Telgte et al (2019) The Contribution of Acute Infarcts to Cerebral Small Vessel Disease Progression Link
Wei et.al. (2019) A Non-linear Association Between Total Small Vessel Disease Score and Hemorrhagic Transformation After Ischemic Stroke With Atrial Fibrillation and/or Rheumatic Heart Disease. Link
June
Chen et.al. (2019) Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke. Link
Du and Xu (2019). SVN. Neuroimaging studies on cognitive impairment due to cerebral small vessel disease. Access here
Jiang (2019) SVN. MRI and glymphatic system. Access here
Liu et.al. (2019) The global burden of cerebral small vessel disease related to neurological deficit severity and clinical outcomes of acute ischemic stroke after IV rt-PA treatment. Link
Dichgans et al. (2019) Lancet Neurol. Stroke genetics: discovery, biology, and clinical applications
Liang et.al. (2019) Exploring causal pathways linking cerebral small vessel diseases burden to poststroke depressive symptoms with structural equation model analysis. Link
Gyanwali et. al. (2019) Cerebral Small Vessel Disease and Enlarged Perivascular Spaces-Data From Memory Clinic and Population-Based Settings. Link
May
Banerjee et.al. (2019) Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or TIA. Link
Chen et.al. (2019) Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease. Link
Das et.al. (2019) Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies. Link
Li et.al. (2019) The relationship between blood-brain barrier permeability and enlarged perivascular spaces: a cross-sectional study. Link
Nam et.al. (2019) Left ventricular ejection fraction is associated with small vessel disease in ischaemic stroke patients. Link
Tejada de Rink et.al. (2019) A Single Injection of N-Oleoyldopamine, an Endogenous Agonist for Transient Receptor Potential Vanilloid-1, Induced Brain Hypothermia, but No Neuroprotective Effects in Experimentally Induced Cerebral Ischemia in Rats. Link
Parella et.al. (2019) The Role of Mast Cells in Stroke. Link
Thomas et.al. (2019) Aortic Pulsatility Propagates Intracranially and Correlates with Dilated Perivascular Spaces and Small Vessel Compliance. Link
April
Chang et.al. (2019) Interarm Blood Pressure Difference has Various Associations with the Presence and Burden of Cerebral Small-Vessel Diseases in Noncardioembolic Stroke Patients. Link
Staszewski et.al (2019) Cerebral and Extracerebral Vasoreactivity in Patients With Different Clinical Manifestations of Cerebral Small-Vessel Disease: Data From the Significance of Hemodynamic and Hemostatic Factors in the Course of Different Manifestations of Cerebral Small-Vessel Disease Study. Link
March
Bouvy et.al. (2019) Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer's disease: A 7 Tesla MRI study. Link
Lu et.al. (2019) Extracranial Artery Stenosis Is Associated With Total MRI Burden of Cerebral Small Vessel Disease in Ischemic Stroke Patients of Suspected Small or Large Artery Origins. Link
Pasi et.al. (2019) Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage. Link
Passiak et.al. (2019) Perivascular spaces contribute to cognition beyond other small vessel disease markers. Link
Schrimer et al (2019) Spatial Signature of White Matter Hyperintensities in Stroke Patients Link
Yamada et.al. (2019) Location-specific characteristics of perivascular spaces as the brain's interstitial fluid drainage system. Link
Yakushiji et. al. (2019) Distribution of cerebral microbleeds in the East and West. Link
Zhang et.al. (2019) Prevalence and risk factors of perivascular space in the population of Shunyi Study. Link
February
Akinyemi et.al. (2019) Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. Link
Ryu et.al. (2019) Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model. Link
January
Feng et.al. (2019) 25-Hydroxy vitamin D level is associated with total MRI burden of cerebral small vessel disease in ischemic stroke patients. Link
Jiang et.al.(2019) Total MRI burden of cerebral vessel disease correlates with the progression in patients with acute single small subcortical strokes. Link
Li et. al. (2019) Incidental findings on brain MRI among Chinese at the age of 55-65 years: the Taizhou Imaging Study. Link
Traylor et. al. (2019). Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226). Link
2018
December
Howe et.al (2018) Fibronectin induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β in aging and after stroke. Link
Li et.al. (2018) Cerebral Small Vessel Disease. Link
Shwarz et.al. (2018) Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson's disease. Link
Yilmaz et.al. (2018) Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death. Link
November
Kang et.al. (20180 Association between periodic limb movements during sleep and cerebral small vessel disease. Link
Su et.al. (2018) The consequence of cerebral small vessel disease: Linking brain atrophy to motor impairment in the elderly. PMID: 29956412
October
Chen et.al. (2018) Cerebral small vessel disease: neuroimaging markers and clinical implication. Link
Shi et.al. (2018) Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow. Link
Ombergen et. al. (2018) Brain Tissue-Volume Changes in Cosmonauts. Link
September
Cuadrado-Godia et.al. (2018) Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies. Link
August
Feng et.al. (2018) Letter by Feng et al Regarding Article, "Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease". Link
Hilal et.al. (2018) Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies. Link
Martinez-Ramirez et.al. (2018) Perivascular Spaces Volume in Sporadic and Hereditary (Dutch-Type) Cerebral Amyloid Angiopathy. Link
Yang et.al. (2018) Twenty-four-hour ambulatory blood pressure variability is associated with total magnetic resonance imaging burden of cerebral small-vessel disease. Link
July
Da Mesquita et al. (2018) Nature. Functional aspects of meningeal lymphatics in aging and Alzheimer's disease. PMID: 30046111
Ghezali et al. (2018) Ann Neurol. Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice. PMID: 30014602
Goodman et al. (2018). Brain Behav Immun. Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects. PMID: 30055243
Harrison et al. (2018). Elife. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with DTI MRI. PMID: 30063207
Rey and Sarntinoranont (2018). Fluids Barriers CNS. 15(1):20. Pulsatile flow drivers in brain parenchyma and perivascular spaces: a resistance network model study. PMID: 30012159
Ringstad et al. (2018). JCI Insight. 3(13). Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. PMID: 29997300
Zellner et al. (2018) Acta Neuropathol. 136(1):111-125. CADASIL brain vessels show a HTRA1 loss-of-function profile. PMID: 29725820
June
Faghih and Sharp (2018) Fluids barriers CNS. 15(1):17. Is bulk flow plausible in perivascular, paravascular and paravenous channels? PMID: 29903035
Thomas et al. (2018) Neuroimage 173:25-34. Impact of time-of-day on diffusivity measures of brain tissue derived from diffusion tensor imaging. PMID: 29458189
van Middelaar et. al. (2018) Effect of Antihypertensive Medication on Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis. PMID:
May
Alboargothy et al. (2018) Acta Neuropathol. Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brainalong separate periarterial basement membrane pathways. PMID: 29754206
Bower and Hogan (2018) J Mol Med (Berl) 96(5):383-390. Brain drains: new insights into brain clearance pathways from lymphatic biology. PMID: 29610928
Huneau et al. (2018) Ann Clin Transl Neurol 5(7):788-802. Altered dynamics of neurovascular coupling in CADASIL. PMID: 30009197
Nakada and Kwee (2018) Neuroscientist Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain. PMID: 29799313
April
Ratelade et al. (2018) J Pathol. 244(4):408-420. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. PMID: 29266233
Taoka et al. (2018) Invest Radiol. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain: Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations. PMID: 29652699
March
Verheggen et al. (2018) Neurosci Biobehav Rev 90:26-33. Interaction between blood-brain barrier and glymphatic system in solute clearance. PMID: 29608988
Huber et al. (2018) Neuroreport. Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. PMID: 29481527
Benias et al. (2018) Sci Rep. 8(1):4947. Structure and Distribution of an Unrecognized Interstitium in Human Tissues. PMID: 29588511
Abbott et al. (2018) Acta Neuropathol 135(3):387-407. The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system? PMID: 29428972
Frosen and Joutel (2018) Cardiovasc Res 114(4):501-512. Smooth muscle cells of intracranial vessels: from development to disease. PMIS: 29351598
February
Rainey-Smith et al. (2018) Transl Psychiatry 8(1):47. Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. PMID: 29479071
January
Gakuba et al. (2018) Theranostics 8(3):710-722. General anesthesia inhibits the activity of the "glymphatic system". PMID: 29344300
Eide and Ringstad (2018) J Cereb Blood Flow Metab. Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study. PMID: 29485341
2017
October
Absinta et al. (2017) Elife. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualised noninvasively by MRI. PMID: 28971799
September
Sun et al. (2017) Prog Neurobiol. Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases. PMID: 28903061
Yang et al. (2017) Neurol Res. Higher ambulatory systolic blood pressure independently associated with enlarged perivascular spaces in basal ganglia. PMID: 28475469
August
Ringstad et al. (2017) Brain. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Access here
Smith et al. (2017) Elife. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4 independent solute transport in rodent brain parenchyma. PMID: 28826498
Nakada et al. (2017) Int J Mol Sci. Aquaporin-4 funcitonality and Virchow-Robin space water dynamics: Physiological model for neurovascular coupling and glymphatic flow. PMID: 28820467
Kapasi et al. (2017) Acta Neuropathol. Impact of multiple pathologies on the threshold for clinically overt dementia. PMID: 28488154
July
Gottesman et al. (2017) JAMA Neurol. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. PMID: 28783817
Machuca-Parra et al. (2017) J Exp Med. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. PMID: 28698285
Ding et al. (2017). JAMA Neurol. Large Perivascular Spaces Visible of Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia: The Age, Gene/Environment Susceptibility-Reykjavik Study. PMID: 28715552
Rauscher et al. (2017) AJNR Am J Neuroradiol. Cerebral microbleeds: A call for standardized advanced neuroimaging. PMID: 28705820
June
Blanco et al. (2017) Stroke and Vascular Neurology. Blood pressure gradients in cerebral arteries: a clue to pathogenesis of cerebral small vessel disease. Access here
Rivera-Rivera et al. (2017) J Cereb Blood Flow Metab. 37(6):2149-2158. Changes in intracranial venous blood flow and pulsatility in Alzheimer's disease: A 4D flow MRI study. PMID 27492950
Shenkin et al. (2017) Neuroimage 153:399-409. Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group. PMID 28232121
May
Park et al. (2017). Circ Res. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aß Peptides. PMID 28515043
Chui and Ramirez-Gomez (2017). Neurol Clin. 35(2):295-323. Vascular Contributions to Cognitive Impairment in Late Life PMID: 28410661
Clinical Science themed collection: Small vessels, dementia and chronic disease. Access here
April
Bedussi et al. (2017). Sci Rep 7:744. Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats PMID: 28389645
Ezzati et al. (2017). J Am Geriatr Soc. Association Between Vascular Pathology and Rate of Cognitive Decline Independent of Alzheimer's Disease Pathology.PMID: 28407205
Holm et al. (2017). J Intern Med. Biomarkers of microvascular endothelial dysfunction predict incident dementia: a population-based prospective study. PMID: 28407377
Joo et al. (2017). Sci Rep 7:464-427. Early neurovascular dysfunction in a transgenic rat model of Alzheimer’s disease. PMID: 28401931
Joutel and Chabriat (2017) Clin Sci (Lond) 131(8):635-651. Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms. PMID: 28351960
March
Gutierrez et al. 2017. Am J Neuroradiol Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study. PMID: 28341719
Held et al. 2017 Clin Sci. Vascular basement membrane alterations and β-amyloid accumulations in an animal model of cerebral small vessel disease PMID: 28348005
Zhang et al. 2017. IEEE Trans Biomed Eng. Structured Learning for 3D Perivascular Spaces Segmentation Using Vascular Features.. PMID: 28362579