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July 2018

Da Mesquita et al. (2018) Nature. Functional aspects of meningeal lymphatics in aging and Alzheimer's disease. PMID: 30046111

Ghezali et al. (2018) Ann Neurol. Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice. PMID: 30014602

Goodman et al. (2018). Brain Behav Immun. Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects. PMID: 30055243

Harrison et al. (2018). Elife. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with DTI MRI. PMID: 30063207

Rey and Sarntinoranont (2018). Fluids Barriers CNS. 15(1):20. Pulsatile flow drivers in brain parenchyma and perivascular spaces: a resistance network model study. PMID: 30012159

Ringstad et al. (2018). JCI Insight. 3(13). Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. PMID: 29997300

Zellner et al. (2018) Acta Neuropathol. 136(1):111-125. CADASIL brain vessels show a HTRA1 loss-of-function profile. PMID: 29725820

June 2018

Faghih and Sharp (2018) Fluids barriers CNS. 15(1):17. Is bulk flow plausible in perivascular, paravascular and paravenous channels? PMID: 29903035

Thomas et al. (2018) Neuroimage 173:25-34. Impact of time-of-day on diffusivity measures of brain tissue derived from diffusion tensor imaging. PMID: 29458189

May 2018

Alboargothy et al. (2018) Acta Neuropathol. Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brainalong separate periarterial basement membrane pathways. PMID: 29754206

Bower and Hogan (2018) J Mol Med (Berl) 96(5):383-390. Brain drains: new insights into brain clearance pathways from lymphatic biology. PMID: 29610928

Huneau et al. (2018) Ann Clin Transl Neurol 5(7):788-802. Altered dynamics of neurovascular coupling in CADASIL. PMID: 30009197

Nakada and Kwee (2018) Neuroscientist Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain. PMID: 29799313

April 2018

Ratelade et al. (2018) J Pathol. 244(4):408-420. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. PMID: 29266233

Taoka et al. (2018) Invest Radiol. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain: Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations. PMID: 29652699

March 2018

Verheggen et al. (2018) Neurosci Biobehav Rev 90:26-33. Interaction between blood-brain barrier and glymphatic system in solute clearance. PMID: 29608988

Huber et al. (2018) Neuroreport. Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. PMID: 29481527

Benias et al. (2018) Sci Rep. 8(1):4947. Structure and Distribution of an Unrecognized Interstitium in Human Tissues. PMID: 29588511

Abbott et al. (2018) Acta Neuropathol 135(3):387-407. The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system? PMID: 29428972

Frosen and Joutel (2018) Cardiovasc Res 114(4):501-512. Smooth muscle cells of intracranial vessels: from development to disease. PMIS: 29351598

February 2018

Rainey-Smith et al. (2018) Transl Psychiatry 8(1):47. Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. PMID: 29479071

January 2018

Gakuba et al. (2018) Theranostics 8(3):710-722. General anesthesia inhibits the activity of the "glymphatic system". PMID: 29344300

Eide and Ringstad (2018) J Cereb Blood Flow Metab. Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study. PMID: 29485341

October 2017

Absinta et al. (2017) Elife. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualised noninvasively by MRI. PMID: 28971799

September 2017

Sun et al. (2017) Prog Neurobiol. Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases. PMID: 28903061

Yang et al. (2017) Neurol Res. Higher ambulatory systolic blood pressure independently associated with enlarged perivascular spaces in basal ganglia. PMID: 28475469

August 2017

Ringstad et al. (2017) Brain. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Access here

Smith et al. (2017) Elife. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4 independent solute transport in rodent brain parenchyma. PMID: 28826498

Nakada et al. (2017) Int J Mol Sci. Aquaporin-4 funcitonality and Virchow-Robin space water dynamics: Physiological model for neurovascular coupling and glymphatic flow. PMID: 28820467

Kapasi et al. (2017) Acta Neuropathol. Impact of multiple pathologies on the threshold for clinically overt dementia. PMID: 28488154

July 2017

Gottesman et al. (2017) JAMA Neurol. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. PMID: 28783817

Machuca-Parra et al. (2017) J Exp Med. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. PMID: 28698285

Ding et al. (2017). JAMA Neurol. Large Perivascular Spaces Visible of Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia: The Age, Gene/Environment Susceptibility-Reykjavik Study. PMID: 28715552

Rauscher et al. (2017) AJNR Am J Neuroradiol. Cerebral microbleeds: A call for standardized advanced neuroimaging. PMID: 28705820

June 2017

Blanco et al. (2017) Stroke and Vascular Neurology. Blood pressure gradients in cerebral arteries: a clue to pathogenesis of cerebral small vessel disease. Access here

Rivera-Rivera et al. (2017) J Cereb Blood Flow Metab. 37(6):2149-2158. Changes in intracranial venous blood flow and pulsatility in Alzheimer's disease: A 4D flow MRI study. PMID 27492950

Shenkin et al. (2017) Neuroimage 153:399-409. Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group. PMID 28232121

May 2017

Park et al. (2017). Circ Res. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aß Peptides. PMID 28515043

Chui and Ramirez-Gomez (2017). Neurol Clin. 35(2):295-323. Vascular Contributions to Cognitive Impairment in Late Life PMID: 28410661

Clinical Science themed collection: Small vessels, dementia and chronic disease. Access here  

April 2017

Bedussi et al. (2017). Sci Rep 7:744. Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats PMID: 28389645

Ezzati et al. (2017). J Am Geriatr Soc. Association Between Vascular Pathology and Rate of Cognitive Decline Independent of Alzheimer's Disease Pathology.PMID: 28407205

Holm et al. (2017). J Intern Med. Biomarkers of microvascular endothelial dysfunction predict incident dementia: a population-based prospective study. PMID: 28407377

Joo et al. (2017). Sci Rep 7:464-427. Early neurovascular dysfunction in a transgenic rat model of Alzheimer’s disease. PMID: 28401931  

Joutel and Chabriat (2017) Clin Sci (Lond) 131(8):635-651. Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms. PMID: 28351960

March 2017

Gutierrez et al. 2017. Am J Neuroradiol Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study. PMID: 28341719

Held et al. 2017 Clin Sci. Vascular basement membrane alterations and β-amyloid accumulations in an animal model of cerebral small vessel disease PMID: 28348005

Zhang et al. 2017. IEEE Trans Biomed Eng. Structured Learning for 3D Perivascular Spaces Segmentation Using Vascular Features.. PMID: 28362579