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Publications related to small vessel disease

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Zheng et al (2022) The association of enlarged perivascular space with microglia-related inflammation and Alzheimer's pathology in cognitively normal elderly

Sun et al (2022) Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Adults with Moyamoya Disease

Ball et al (2022) Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysis



Pinheiro et al (2022) Association of Apolipoprotein E ɛ4 Allele with Enlarged Perivascular Spaces

Kuipers et al (2022) A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease

Wang et al (2022) Severity of Intracranial Large Artery Disease Correlates With Cerebral Small Vessel Disease

Xu et al (2022) Glymphatic dysfunction correlates with severity of small vessel disease and cognitive impairment in cerebral amyloid angiopathy



Xuan et al (2022) Glymphatic System: Emerging Therapeutic Target for Neurological Diseases

Mendes & Velloso (2022) Perivascular macrophages in high-fat diet-induced hypothalamic inflammation

Yan et al (2022) Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer's disease

Mildenberger et al (2022) Diversity and function of brain-associated macrophages

Ibitoye et al (2022) A link between frontal white matter integrity and dizziness in cerebral small vessel disease

Kaczynski et al (2022) 18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome

Duplaa et al (2022) Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate



Gao et al (2022) The Association of Nocturnal Blood Pressure Patterns and Other Influencing Factors With Lacunes and Enlarged Perivascular Spaces in Hypertensive Patients

Neumann et al (2022) Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study

Lao et al (2022) Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum

Yu et al (2022) Perivascular Spaces, Glymphatic System and MR

Mahammedi et al (2022) Small Vessel Disease, a Marker of Brain Health: What the Radiologist Needs to Know



Fu et al (2022) Fundus Changes Evaluated by OCTA in Patients With Cerebral Small Vessel Disease and Their Correlations: A Cross-Sectional Study

Cheng et al (2022) Cerebral small vessel disease and prognosis in intracerebral haemorrhage: A systematic review and meta-analysis of cohort studies

Seki et al (2022) Neuropsychological Profile of Early Cognitive Impairment in Cerebral Small Vessel Disease



Tao et al (2022) Dihydromyricetin ameliorates oxygen‑glucose deprivation and re‑oxygenation‑induced injury in HT22 cells by activating the Wnt/β‑catenin signaling pathway link



Collins-Yoder & Key (2022) Acute ischemic stroke or migraine with aura? Triage considerations link



Jiang et al (2022 Longitudinal white matter hyperintensity changes and cognitive decline in patients with minor stroke link 

Olsen & Andersen (2022) Absolute risk of ischemic and hemorrhagic stroke in Danish women using oral contraceptives link

Shen et al (2022) Prediction of Mechanosensitive Genes in Vascular Endothelial Cells Under High Wall Shear Stress link

Yusuf et al (2022) Roles of Polymorphonuclear Neutrophils in Ischemic Brain Injury and Post-Ischemic Brain Remodeling link

Zhang et al (2022) Evaluation and Prediction of Post-stroke Cerebral Edema Based on Neuroimaging link

Koton et al (2022) Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study link





Cui et al (2021) Risk of ischemic stroke in patients with COVID-19 infection: A systematic review and meta-analysis link

Xie et al (2022) Nomogram to Predict Symptomatic Intracranial Hemorrhage after Intravenous Thrombolysis in Acute Ischemic Stroke in Asian Population link



Moullaali et al (2021) Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data link

Zhang et al (2021) MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure link

Wang et al (2021) Severity of Intracranial Large Artery Disease Correlates With Cerebral Small Vessel Disease link

Kim et al (2021) Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial link

Inkeri et al (2021) Glycemic control is not related to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes link

Lee et al (2021) Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease link

Jiang et al (2021) Association of Serum Interleukin-34 and Insulin Resistance with Cognitive Impairment in Patients with Cerebral Small Vessel Disease link



de Havenon et al (2021) Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities link

Luu et al (2021) The impact of reporting magnetic resonance imaging incidental findings in the Canadian alliance for healthy hearts and minds cohort link

teng et al (2021) Long-Term Use of Metformin Is Associated With Reduced Risk of Cognitive Impairment With Alleviation of Cerebral Small Vessel Disease Burden in Patients With Type 2 Diabetes link

Hautecloque et al (2021) Multifocal and Microvascular Involvement in Ischemic Stroke During COVID-19: A Cohort Study With Comparison With Non-COVID-19 Stroke link

Xu et al (2021) A Novel Imaging Biomarker for Cerebral Small Vessel Disease Associated With Cognitive Impairment: The Deep-Medullary-Veins Score link



Vynckier et al (2021) Phenotypes of Chronic Covert Brain Infarction in Patients With First-Ever Ischemic Stroke: A Cohort Study link

Ball et al (2021) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis link

Shi et al (2021) Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals link

Al-Shahi Salman et al (2021) Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial link

SoSTART Collaboration (2021) Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial Link

Lu et al (2021) The protective effect of harpagoside on angiotensin II (Ang II)-induced blood-brain barrier leakage in vitro link

Simonsen et al (2021) Sleep-disordered breathing and cerebral small vessel disease-acute and 6 months after ischemic stroke link

Nam et al (2021) Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer link

Kuuluvainen et al (2021) COL4A1 and COL4A2 Duplication Causes Cerebral Small Vessel Disease With Recurrent Early Onset Ischemic Strokes link



Xia et al (2021) Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial link

Boulestreau et al (2021) Neurologically asymptomatic patients frequently present cerebral injuries during malignant hypertension: a MRI study link

Zhang et al (2021) Direct endovascular treatment versus bridging therapy in patients with acute ischemic stroke eligible for intravenous thrombolysis: systematic review and meta-analysis link

Takahashi et al (2021) Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke link

Safayet et al (2021) Melatonin and Sleep Disturbances in Alzheimer's Disease link

Guan et al (2021) Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity link



No authors listed (2021) Correction to: 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association Link

Du et al (2021) Multi-Dimensional Diffusion Tensor Imaging Biomarkers for Cognitive Decline From the Preclinical Stage: A Study of Post-stroke Small Vessel Disease link

Muino et al (2021) Contribution of "Omic" Studies to the Understanding of Cadasil. A Systematic Review link

Hu et al (2021) NOTCH3 Variants and Genotype-Phenotype Features in Chinese CADASIL Patients link

Gravestejn et al (2021) NOTCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature link



Yu et al (2021) Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging link

Prasad et al (2021) Cohort profile: The LoCARPoN—a population-based prospective cohort study in middle-aged and older adults in India Link

Zhou et al (2021) Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target. Link

Portilla-Fernandez et al (2021) Meta-analysis of epigenome-wide association studies of carotid intima-media thickness. Link

Pilotto et al (2021) Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders Link

Che Mohd Nassir et al (2021) COVID-19 Infection and Circulating Microparticles-Reviewing Evidence as Microthrombogenic Risk Factor for Cerebral Small Vessel Disease Link

Funck et al (2021) Arterial stiffness and progression of cerebral white matter hyperintensities in patients with type 2 diabetes and matched controls: a 5-year cohort study Link

El Nahas et al (2021) Borderzone Infarction and Small Vessel Disease in a Sample of Egyptian Stroke Patients: Differences and Similarities Link

Pan et al (2021) Hypoxia-inducible factor-1: regulatory mechanisms and drug development in stroke Link



Humpreys et al (2021) Correlations in post-mortem imaging-histopathology studies of sporadic human cerebral small vessel disease: A systematic review. Link

Hachinski et al (2021) A new definition of brain health. Link

Walsh et al (2021) Microglial activation and blood-brain barrier permeability in cerebral small vessel disease. Link

Chen et al (2021) Acute lacunar infarct in an obese adolescent with obstructive sleep apnea. Link

Tsai et al (2021) Variations of risk factors for ischemic stroke and its subtypes in Chinese patients in Taiwan. Link

Sangalli et al (2021) Impact of SARS-CoV-2 infection on acute intracerebral haemorrhage in northern Italy. Link 

Jiang et al (2021) Advances in Understanding the Pathogenesis of Lacunar Stroke: From Pathology and Pathophysiology to Neuroimaging. Link

Wu et al (2021) Edaravone attenuates H 2 O 2 or glutamate-induced toxicity in hippocampal neurons and improves AlCl 3/D-galactose induced cognitive impairment in mice. Link

Wang et al (2021) STC1 ameliorates cognitive impairment and neuroinflammation of Alzheimer's disease mice via inhibition of ERK1/2 pathway. Link

Chevalley et al (2021) Socio-environmental predictive factors for discharge destination after inpatient rehabilitation in patients with stroke: a systematic review and meta-analysis. Link

Cataldo et al (2021) Cortical inflammation and brain signs of high-risk atherosclerosis in a non-human primate model. Link



Kapadia et al (2021) In vivo detection of beta-amyloid at the nasal cavity and other skull-base sites: a retrospective evaluation of ADNI1/GO. Link

Sagnier et al (2021) Severity of Small Vessel Disease Biomarkers Reduces the Magnitude of Cognitive Recovery after Ischemic Stroke Link

Brutto et al (2021) Dietary Oily Fish Intake is Inversely Associated with Severity of White Matter Hyperintensities of Presumed Vascular Origin. A Population-Based Study in Frequent Fish Consumers of Amerindian Ancestry. Link

Jiaerken et al (2021) Dilated perivascular space is related to reduced free-water in surrounding white matter among healthy adults and elderlies but not in patients with severe cerebral small vessel disease. Link

Hausman-Kedem et al (2021) Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations. Link

Vinke et al (2021) Intracranial arteriosclerosis is related to cerebral small vessel disease: a prospective cohort study. Link

Zhang et al (2021) Deep Fusion of Brain Structure-Function in Mild Cognitive Impairment. Link



Rotta et al (2021) Detection of Cerebral Microbleeds With Venous Connection at 7 Tesla MRI Link

Dennis et al (2021) Sex Differences in Stroke Hospitalization Incidence, 30-Day Mortality, and Readmission in a Regional Medical Center in the Southwestern United States Link

Manera et al (2021) MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia Publication link

Chia et al (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Link

Lyden et al (2021) Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation Link

Chojdak-Łukasiewicz et al (2021) Cerebral small vessel disease: A review. Link

Kerkhofs et al (2021) Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities Link

Kwan et al (2021) Cognitive Impairment after Lacunar Stroke and the Risk of Recurrent Stroke and Death Link

Chen et al (2021) Research progress of imaging technologies for ischemic cerebrovascular diseases Link

Ilinca et al (2021) MAP3K6 Mutations in a Neurovascular Disease Causing Stroke, Cognitive Impairment, and Tremor Link



Zhou et al (2021) Low- versus standard-dose alteplase in acute lacunar ischemic stroke: The ENCHANTED Trial Link

Bernal M et al (2021) Differential Characteristics of Ischemic and Hemorrhagic Stroke in Patients with Cerebral Small Vessel Disease Link

Guo et al (2021) Increased insulin resistance is associated with vascular cognitive impairment in Chinese patients with cerebral small vessel disease Link

Karaszewski et al (2021) Efficacy and Safety of Intravenous rtPA in Ischemic Strokes Due to Small-Vessel Occlusion: Systematic Review and Meta-Analysis Link

Geraets et al (2021) The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study Link

Huang et al (2021) White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration Link

Leowenstein & Rabbat (2021) Neurological complications of systemic hypertension Link

Pieruccini-Faria et al (2021) Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study. Link



Saba et al (2021) Multinational Survey of Current Practice from Imaging to Treatment of Atherosclerotic Carotid Stenosis Link 

Zheng et al (2021). GRP per capita and hospital characteristics associated with intravenous tissue plasminogen activator adherence rate: evidence from the Chinese Stroke Center Alliance. Link

Kim et al (2021). Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion. Link

Chen et al (2021). Association of neuroimaging markers of cerebral small vessel disease with short-term outcomes in patients with minor cerebrovascular events. Link

Kim et al (2021). Association of Bone Mineral Density to Cerebral Small Vessel Disease Burden. Link

Bontzos et al (2021). Retinal neurodegeneration, macular circulation and morphology of the foveal avascular zone in diabetic patients: quantitative cross-sectional study using OCT-A Link

Saji et al (2021). The Association between Cerebral Small Vessel Disease and the Gut Microbiome: A Cross-Sectional Analysis. Link

Smith et al (2021) Vascular Contributions to Neurodegeneration: Protocol of the COMPASS-ND Study




Liu et al (2021) Intracranial Atherosclerosis Coexisting With White Matter Hyperintensities May Predict Unfavorable Functional Outcome in Patients With Acute Cerebral Ischemia Link

Tayler et al (2021) Mediators of cerebral hypoperfusion and blood-brain barrier leakiness in alzheimer's disease, vascular dementia and mixed dementia. Link

Bijkerk et al (2021) Circulating angiopoietin-2 and angiogenic microRNAs associate with cerebral small vessel disease and cognitive decline in older patients reaching end stage renal disease Link

Waller et al (2021) Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to alzheimer's and small vessel disease pathologies Link

Delcourt et al (2021) Brain imaging abnormalities and outcome after acute ischaemic stroke: the ENCHANTED trial Link 



Papanastasiou et al (2020) Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18 F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: proof of concept Link

Beishon et al (2020) Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial Link

Rodriques et al (2020) The association between CT biomarkers of cerebral small vessel diseases and long-term outcome after spontaneous intracerebral hemorrhage Link

Camarda et al (2020) APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer's Disease: a Longitudinal Study Link

Annus et al (2020) Connection between small vessel disease related stroke and the MTHFR C677T polymorphism in a Hungarian population Link



Blenvis et al (2020) Brain arteriolosclerosis Link

Wu et al (2020) Intracranial Arterial Calcification Relates to Long-Term Risk of Recurrent Stroke and Post-stroke Mortality Link

Hansen et al (2020) Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III Link

Mair et al (2020) Feasibility and diagnostic accuracy of using brain attenuation changes on CT to estimate time of ischemic stroke onset Link

Delcourt et al (2020) Brain imaging abnormalities and outcome after acute ischaemic stroke: the ENCHANTED trial Link

Muir (2020) Prognostic value of acute CT in stroke thrombolysis Link

Colelli et al (2020) Feasibility of unattended home sleep apnea testing in a cognitively impaired clinic population Link

Ganesh et al (2020) Trial of remote ischaemic preconditioning in vascular cognitive impairment (TRIC-VCI): protocol Link

Franzmeier et al (2020) Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration Link



Zhang et al (2020) Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture Link

Umemura et al (2020) Oral anticoagulant use and the development of new cerebral microbleeds in cardioembolic stroke patients with atrial fibrillation Link

You et al (2020) Plasma lipidomic analysis of sphingolipids in patients with large artery atherosclerosis cerebrovascular disease and cerebral small vessel disease Link 

Imam et al (2020) Stroke in the adult Qatari population (Q-stroke) a hospital-based retrospective cohort study Link

Pålhaugen et al (2020) Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns Link

Brutto et al (2020) Dawson Fingers in Older Adults with Cerebral Small Vessel Disease: A Population Study Link

Pan et al (2020) Brain structural changes in CADASIL patients: A morphometric magnetic resonance imaging study Link

Moreton et al (2020) Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over two year follow up Link

Liu et al (2020) Uncontrolled hypertension associates with subclinical cerebrovascular health globally: a multimodal imaging study Link

Varkanitsa et al (2020) White Matter Hyperintensities Predict Response to Language Treatment in Poststroke Aphasia Link

Jaworek et al (2020) Exome Array Analysis of Early-Onset Ischemic Stroke Link

Wong et al (2020) Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment Link

Knol et al (2020) Association of common genetic variants with brain microbleeds: A Genome-wide Association Study Link

Kneihsl et al (2020) Intracranial Pulsatility in Relation to Severity and Progression of Cerebral White Matter Hyperintensities Link

Pasi et al (2020) Long-term mortality in survivors of spontaneous intracerebral hemorrhage Link

Giannetto et al (2020) Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice Link



Sliz et al (2020) Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids Link

Wu et al (2020) Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status Link

Mok et al (2020) Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future Link

Porcu et al (2020) Extracranial Carotid Artery Stenosis: The Effects on Brain and Cognition with a Focus on Resting-State Functional Connectivity Link

Anagnostou et al (2020) Bedside Assessment of Vergence in Stroke Patients Link

Liao et al (2020) Mitochondrial DNA m.3243A>G mutation rarely causes CADASIL-like phenotype Link

Rannikmäe et al (2020) Beyond the Brain: Systematic Review of Extracerebral Phenotypes Associated With Monogenic Cerebral Small Vessel Disease Link 



Stæger et al (2020) A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices Link

Kwong et al (2020) Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma Link

Arrelanes et al (2020) Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial Link

Mukherjee et al (2020) 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase Link

Ohene et al (2020) Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI Link



Varatharaj et al (2020) Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study Link

Anad et al (2020) Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease Link

Zukotynski et al (2020) The Use of Random Forests to Identify Brain Regions on Amyloid and FDG PET Associated With MoCA Score Link



Larsen et al (2020) Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep Link

Olsen et al (2020) Peripheral Electrical Stimulation Paired With Movement-Related Cortical Potentials Improves Isometric Muscle Strength and Voluntary Activation Following Stroke Link 



Ratelade et al (2020) Reducing Hypermuscularization of the Transitional Segment between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage. Link

Lazic et al (2020) Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease Link

Olama et al (2020) Simple MRI score aids prediction of dementia in cerebral small vessel disease. Link

He et al. (2020) Homozygous NOTCH3 p.R587C mutation in Chinese patients with CADASIL: a case report. Link

Grasby et al (2020) The genetic architecture of the human cerebral cortex. Link

Nagaraja et al (2020) Reversible diffusion-weighted imaging lesions in acute ischemic stroke Link

Zhu et al (2020) Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy Link



Harris et al (2020) Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age Link

Biton et al (2020) Polygenic Architecture of Human Neuroanatomical Diversity Link 

Wang et al. (2020) Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease. Link

Robalo et al. (2020) Effect of fixed-density thresholding on structural brain networks: a demonstration in cerebral small vessel disease. Link

van Veluw et al. (2020) Editorial: Cerebral Small Vessel Diseases: From Vessel Alterations to Cortical Parenchymal Injury Link

Contreras et al (2020) Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers Link

Hauglund et al. (2020). Meningeal lymphangiogenesis and enhanced glymphatic activity in mice with chronically implanted EEG electrodes Link

Hussein et al. (2020). The association between resting‐state functional magnetic resonance imaging and aortic pulse‐wave velocity in healthy adults. Link

Garnier-Crussard et al. (2020) White matter hyper-intensities in ageing: Pathophysiology, associated cognitive disorders and prevention Link

Vernooij & Buchem (2020) Neuroimaging in Dementia. Link

Yuan et al. (2020) Single nucleotide polymorphism of MTHFR rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease. Link

Liu et al. (2020) Fiber Connectivity Density in Cerebral Small-Vessel Disease Patients With Mild Cognitive Impairment and Cerebral Small-Vessel Disease Patients With Normal Cognition. Link

Yatawara et al. (2020) The role of cerebral microbleeds in the incidence of post-stroke dementia. Link

Suzuyama et al. (2020) Total small vessel disease score and cerebro-cardiovascular events in healthy adults: The Kashima scan study. Link

Zheng et al. (2020) Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: the first multicentre, phase III trial in China Link



Lemmens et al. (2020) Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker. Link

Dawe et al. (2020) Late-life cognitive decline is associated with hippocampal volume, above and beyond its associations with traditional neuropathologic indices Link

Zhai et al.(2020) Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling Pathway Link

Caldwell et al. (2020) Evidence for temperature-mediated regional increases in cerebral blood flow during exercise Link

Holmsquist et al.  (2020) The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016 Link

Wouts et al. (2020) Empirical support for the vascular apathy hypothesis: A structured review Link

Zhu et al. (2020) Reduced Levels of Cerebrospinal Fluid/Plasma Aβ40 as an Early Biomarker for Cerebral Amyloid Angiopathy in RTg-DI Rats Link

Ge et al. (2020) Analysis of young ischemic stroke patients in northeast China. Link

Moodie et al (2020) Fluctuating asymmetry in brain structure and general intelligence in 73-year-olds Link 




Zhou et al. (2019) Irregular surface of carotid atherosclerotic plaque is associated with ischemic stroke: a magnetic resonance imaging study Link

Xu et al. (2019) Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis Link

Han et al. (2019) A Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes: Protocol of a Multicenter, Randomized Controlled Trial Link

Neves et al (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL Link



Fultz et. al. (2019) Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep Link

Grifin el.al. (2019) Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Link

Liang et.al. (2019) Cerebral Small Vessel Disease Burden Is Associated With Accelerated Poststroke Cognitive Decline: A 1-Year Follow-Up Study. Link

Lo et. al. (2019) Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups. Link

Qu et.al. (2019) Preexisting Cerebral Abnormalities and Functional Outcomes After Acute Ischemic Stroke. Link

Wang et.al. (2019) Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study. Link

Huang et. al. (2019) Association of obstructive sleep apnea and cerebral small vessel disease: a systematic review and meta-analysis Link



Chung et al (2019) Genome-wide association study of cerebral small vessel disease reveals established and novel loci. Link

Denver et. al. (2019) A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer’s Disease Link

Dobrynina et.al. (2019) Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease. Link

Goldstein et.al. (2019) Cerebral Small Vessel Disease Burden and All-Cause Mortality: Mayo Clinic Florida Familial Cerebrovascular Diseases Registry. Link

Raz et.al. (2019) Possible Empirical Evidence of Glymphatic System on CT after Endovascular Perforations. Link

Villeneuve S (2019) Lifespan Cognitive Reserve—A Secret to Coping With Neurodegenerative Pathology. Link

Neves et al. (2020) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL



Brutto et.al. (2019) Effect of Heart Rate Variability on the Association Between the Apnea-Hypopnea Index and Cerebral Small Vessel Disease. Link

Duperron et.al. (2019) High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage. Link

Faraco et.al. (2019) Dietary salt promotes cognitive impairment through tau phosphorylation. PDF



Hernández-Díaz et.al. (2019) Cerebral Small Vessel Disease Associated with Subclinical Vascular Damage Indicators in Asymptomatic Hypertensive Patients. Link

Huo et. al. (2019) Total Small Vessel Disease Burden Predicts Functional Outcome in Patients With Acute Ischemic Stroke. Link

Kubota et.al. (2019) Association Between Cerebral Small Vessel Disease and Central Motor Conduction Time in Patients with Vascular Risk. Link

Gutierrez at.al. (2019) Brain arterial dilatation modifies the association between extracranial pulsatile hemodynamics and brain perivascular spaces: the Northern Manhattan Study. Link

Low et.al. (2019) Inflammation and cerebral small vessel disease: A systematic review. Link

Park et.al. (2019) MRI Assessment of Cerebral Small Vessel Disease in Patients with Spontaneous Intracerebral Hemorrhage. Link

Reginold et al. (2019) The efficiency of the brain connectome is associated with cerebrovascular reactivity in persons with white matter hyperintensities. Link

Roth et.al. (2019) Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke. Link

Shreiber et.al. (2019) Invited Review: The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies. Link

Sorond & Gorelick (2019) Brain White Matter: A Substrate for Resilience and a Substance for Subcortical Small Vessel Disease. Link

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Clinical Science themed collection: Small vessels, dementia and chronic disease. Access here  


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