Home » Network Publications

Publications from network members since the project began

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Mishra et al (2022) Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate



Jochems et al (2022) Contribution of white matter hyperintensities to ventricular enlargement in older adults

Wardlaw and Liebeskind (2022) Not Just Blood: Brain Fluid Systems and Their Relevance to Cerebrovascular Diseases

Berezuk et al (2022) Cognitive reserve, cognition, and real-world functioning in MCI: A systematic review and meta-analysis

Aydin et al (2022) The oxygen initial dip in the brain of anesthetized and awake mice



Winkler et al (2022) A single-cell atlas of the normal and malformed human brain vasculature

Schrader et al (2022) Emergent White Matter Degeneration in the rTg-DI Rat Model of Cerebral Amyloid Angiopathy Exhibits Unique Proteomic Changes

Ozzoude et al (2022) Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases

Ladrón-de-Guevara et al (2022) Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment



Wardlaw, Benveniste and Williams (2022) Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies

Beaman et al (2022) Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension

Wiseman et al (2022) Measuring axial length of the eye from magnetic resonance brain imaging

Clancy et al (2022) Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke

Chen et al (2022) Perivascular space in Parkinson's disease: Association with CSF amyloid/tau and cognitive decline

Oka et al (2022) CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis

Benveniste & Nedergaard (2022) Cerebral small vessel disease: A glymphopathy?

Luciw et al (2022) Automated generation of cerebral blood flow and arterial transit time maps from multiple delay arterial spin-labeled MRI

Beaman et al (2022) Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension

Barisano et al (2022) Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease



Huuskonen et al (2022) Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C

Sliz et al (2022) Circulating Metabolome and White Matter Hyperintensities in Females and Males

McCartney et al (2022) Blood-based epigenome-wide analyses of cognitive abilities





Martikainen et al (2022) TUBE Project: Transport-Derived Ultrafines and the Brain Effects

Blair et al (2021) Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial

Conosole et al (2021) DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging



Stringer et al (2021) Tracer kinetic assessment of blood-brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors

Huuskonen MT et al (2021) Editorial for "MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure"

Callahan et al (2021) Cognitive and Neuroimaging Profiles of Older Adults With Attention Deficit/Hyperactivity Disorder Presenting to a Memory Clinic.

Huuskonen et al (2021) Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion

Sapkota et al (2021) Differential Cognitive Decline in Alzheimer's Disease Is Predicted by Changes in Ventricular Size but Moderated by Apolipoprotein E and Pulse Pressure

MacIntosh et al (2021) Brain structure and function in people recovering from COVID-19 after hospital discharge or self-isolation: a longitudinal observational study protocol



Battistella et al (2021) Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature.

Wardlaw et al (2021) Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies

Jiménez-Sánchez et al (2021) Sex differences in cerebral small vessel disease: a systematic review and meta-analysis

Zhang et al (2021) Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease

Elkin et al (2021) Fisher-Rao Regularized Transport Analysis of the Glymphatic System and Waste Drainage

Chagnot et al (2021) Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia

Hablitz & Nedergaard (2021) The glymphatic system




Backhouse et al (2021) Early life predictors of late life cerebral small vessel disease in four prospective cohort studies

Wardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid production

Hamilton et al (2021) Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

Benveniste & Nedergaard (2021) Cerebral small vessel disease: A glymphopathy?

Xiong et al (2021) Leukotriene receptor antagonist use and cognitive decline in normal cognition, mild cognitive impairment, and Alzheimer's dementia

Kisler et al (2021) Microglia have a grip on brain microvasculature

Du et al (2021) Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.

Hablitz & Nedergaard (2021) The Glymphatic System: A Novel Component of Fundamental Neurobiology.




Weather et al (2021) Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing

Liu et al (2021) Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model

Rosehart et al (2021) Prostaglandin E 2 Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases

Rajani et al (2021) Characterisation of early ultrastructural changes in the cerebral white matter of CADASIL small vessel disease using high-pressure freezing/freeze-substitution

Benveniste & Neredgard (2021) Cerebral small vessel disease: A glymphopathy?



Rungta et al (2021) Diversity of neurovascular coupling dynamics along vascular arbors in layer II/III somatosensory cortex

Huuskonen et al (2021) Editorial for "MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure"

Huuskonen et al (2021) On the intersection between systemic infection, brain vascular dysfunction and dementia

MacIntosh et al (2021) Diabetes Mellitus Is Associated With Poor In-Hospital and Long-Term Outcomes in Young and Midlife Stroke Survivors

Desmarais et al (2021) White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer's disease

Hamilton et al (2021) Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936

Zhang et al (2021) Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease

Wardlaw et al (2021) A Stroke Is a Stroke, With or Without a Visible Infarct

Procter et al (2021) Interplay between brain pericytes and endothelial cells in dementia

Giannonni et al (2021) A Hyperspectral Imaging System for Mapping Haemoglobin and Cytochrome-c-Oxidase Concentration Changes in the Exposed Cerebral Cortex

Wardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid production

Bernal et al (2021) Selective Motion Artefact Reduction via Radiomics and k-space Reconstruction for Improving Perivascular Space Quantification in Brain Magnetic Resonance Imaging

Blair et al (2021) Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project




Stringer et al (2021) A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease

Stanton et al (2021) Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: effect of anesthesia

Hamilton & Wardlaw (2021) Response to Schroeter ML, Letter, Small vessel disease and social cognition

Stringer et al (2021) A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease

Wiegertjes et al (2021) Diffusion-weighted imaging lesions and risk of recurrent stroke after intracerebral haemorrhage

Zhu et al (2021) Alzheimer's pathogenic mechanisms and underlying sex difference

Aydin et al (2021) Iliski, a software for robust calculation of transfer functions

Bakhsheshian et al (2021) Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques




Valdés Hernández et al (2021) White Matter Hyperintensities Evolution Patterns 1 Year Post-lacunar Stroke and their association with post-stroke cognition

Castorina et al (2021) Metrics for quality control of results from super-resolution machine-learning algorithms – Data extracted from publications in the period 2017- May 2021

Morrison & Valdés Hernández (2021) Systematic Review and Meta-Analysis on incidence and risk of stroke in individuals with long-term exposure to air pollutants




Morrison et al (2021) Potential recruitment into a clinical trial of vascular secondary prevention medications in cerebral small vessel disease, based on concomitant medication use

Rasmussen et al (2021) Fluid Transport in the Brain

Manning et al (2021) Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage

Stewart et al (2021) Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis

van der Brink et al (2021) Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” study

Buchanan et al (2021) Comparison of structural MRI brain measures between 1.5 and 3 T: Data from the Lothian Birth Cohort 1936

Sajic et al (2021) High Dietary Fat Consumption Impairs Axonal Mitochondrial Function In Vivo

Boyle et al (2021) Artificial intelligence for molecular neuroimaging

Albrecht et al (2021) Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults



Bernal (2021) Systematic review of signal post-processing methods in blood-brain barrier dysfunction assessments via dynamic-contrast enhanced magnetic resonance imaging

Humphreys & Valdés Hernández (2021) Systematic Review and Meta-Analysis on the Impact of Polycyclic Aromatic Hydrocarbons Exposure in Cognitive Function and Neurodegeneration in Humans 

Valdés Hernández (2021) Human Brain Atlases across the lifespan – Anatomical Segmentations



Ramirez et al (2021) MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease

Veawer et al (2021) Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Madole et al (2021) Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines

Bernal et al (2021) A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage

Best et al (2021) Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Nikolakopoulou et al (2021) Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A

Bakhsheshian et al (2021) Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques

Zhu et al (2021) Alzheimer's pathogenic mechanisms and underlying sex difference

Dabertrand et al (2021) PIP 2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity



Valdes-Hernandez et al (2021) Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke

Valdes-Hernandez et al (2021) Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar Stroke

Taylor et al (2021) Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

Liebeskind & Wardlaw (2021) Imaging Advances: Acute-on-Chronic Stroke

Clancy et al (2021) Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis

Cuttler et al (2021) Low Doses of Ionizing Radiation as a Treatment for Alzheimer’s Disease: A Pilot Study

Ouk et al (2021) The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status

Clancy et al (2021) Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Rajna et al (2021) Cardiovascular brain impulses in Alzheimer's disease

Raghunandan et al (2021) Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

Sajic et al (2021) High dietary fat consumption impairs axonal mitochondrial function in vivo

Covan et al (2021) Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen

Lyden et al (2021) Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation



Gorelick PB, Testai FD, Hankey GJ, Wardlaw JM (2021). "Hankey's Clinical Neurology" (3rd Edition)  20% discount available with a flyer Link 

Verdelho et al (2021) Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee

Verdelho et al (2021) Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee – A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics

Rodriguez et al (2021) Association between Computed Tomographic Biomarkers of Cerebral Small Vessel Diseases and Long-Term Outcome after Spontaneous Intracerebral Hemorrhage

Stringer et al (2021) A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

Ntiri et al (2021) Improved Segmentation of the Intracranial and Ventricular Volumes in Populations with Cerebrovascular Lesions and Atrophy Using 3D CNNs



Papanastasiou et al (2021) Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of concept

Cox et al (2021) Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life

Burhan et al (2021) Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics

Albrecht et al (2021) Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults

Yu et al (2021) Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis

Stanton et al (2021) Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia

Ozturk et al (2021) Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics

Rajani et al (2021) Characterization of early ultrastructural changes in the cerebral white matter of CADASIL small vessel disease using high pressure freezing/freeze-substitution

Giannoni et al (2021) A hyperspectral imaging system for mapping haemoglobin and cytochrome-c-oxidase concentration changes in the exposed cerebral cortex




Quick et al (2020). A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease

Sargurupremraj et al (2020) Cerebral small vessel disease genomics and its implications across the lifespan

Valdes-Hernandez et al (2020) Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus

Doubal et al (2020) Response by Doubal et al to Letter Regarding Article, "Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis"

Corley et al (2020) Dietary patterns, cognitive function, and structural neuroimaging measures of brain aging

Ouk et al (2020) Associations between brain amyloid accumulation and the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers

Ouk et al (2020) Depression and Diabetes Mellitus Multimorbidity Is Associated With Loss of Independence and Dementia Poststroke

Benveniste et al (2020) The glymphatic system and its role in cerebral homeostasis

Liu et al (2020) Direct Measurement of Cerebrospinal Fluid Production in Mice

Fontaine et al (2020) HB-EGF depolarizes hippocampal arterioles to restore myogenic tone in a genetic model of small vessel disease



[Book chapter] Doubal, [...], Wardlaw (2020). Section 4 Vascular Disease, Chapter 21, Small vessel disease. In Brayne C, Feigin V, Launer L, Logroscino G, eds. Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology. Oxford University Press, Oxford, 2020. DOI link: 10.1093/med/9780198749493.001.0001

Wu et al (2020) Hyperdense artery sign, symptomatic infarct swelling and effect of alteplase in acute ischaemic stroke

Loan et al (2020) Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study

Green et al (2020) Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder

Hertzel et al (2020) Diabetes, Brain Infarcts, Cognition and Small Vessels in the Canadian Alliance for Healthy Hearts and Minds Study

Rivas et al (2020) Surface periarterial spaces of the mouse brain are open, not porous

Hamilton et al (2020) Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta‐analysis

Balakrishnan et al (2020) Automatic Segmentation of White Matter Hyperintensities from Brain Magnetic Resonance Images in the Era of Deep Learning and Big Data – A Systematic Review

Zhou et al (2020) Intensive versus guideline-recommended blood pressure reduction in acute lacunar stroke with intravenous thrombolysis therapy: The ENCHANTED trial 

Shao et al (2020) Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort

Benveniste et al (2020) Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging



Stewart et al (2020) Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis

Clancy et al (2020) Clinical management of cerebral small vessel disease: a call for a holistic approach

Corley et al (2020) Dietary patterns, cognitive function, and structural neuroimaging measures of brain ageing

Rekik et al (2020) Predictive Intelligence in Medicine (book)

Zhao & Zlokovic (2020) Endothelial Tip Cell Finds Its Way with Piezo1

Albrecht et al (2020) Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid

Zlokovic et al (2020) Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop

Allenbach et al (2020) Immune-mediated necrotizing myopathy: clinical features and pathogenesis

Nedergaard & Goldman (2020) Glymphatic failure as a final common pathway to dementia

Elkin et al (2020) Fisher-Rao Regularized Transport Analysis of the Glymphatic System and Waste Drainage

Cunniffe et al (2021). Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis



Ballerini et al (2020) Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects

Stringer et al (2020). A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease.

Zhang et al (2020). The Application of Optical Coherence Tomography Angiography in Cerebral Small Vessel Disease, Ischemic Stroke, and Dementia: A Systematic Review.

Hablitz et al (2020) Circadian control of brain glymphatic and lymphatic fluid flow

Xue et al (2020) In vivo T1 mapping for quantifying glymphatic system transport and cervical lymph node drainage

Wardlaw et al (2020) Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease



Lee et al (2020) Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy ​​​​​

Ramirez et al (2020) Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI Methods and Outcome Measures



Rachmadi et al (2020) Automatic spatial estimation of white matter hyperintensities evolution in brain MRI using disease evolution predictor deep neural networks

Carare et al (2020) Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer’s disease-Opportunities for Therapy

Zhao & Zlokovic (2020) Therapeutic TVs for Crossing Barriers in the Brain

Mestre et al (2020) The Brain's Glymphatic System: Current Controversies



Bernal et al (2020) Examining the relationship between semiquantitative methods analysing concentration-time and enhancement-time curves from dynamic-contrast enhanced magnetic resonance imaging and cerebrovascular dysfunction in small vessel disease

Clancy et al (2020) Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3 

Kisler et al (2020) Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature

Sweeney et al (2020) A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid

Aydin et al (2020) Transfer functions linking neural calcium to single voxel functional ultrasound signal



Arba et al (2020) Improving Clinical Detection of Acute Lacunar Stroke: Analysis From the IST-3.

Jochems et al (2020) Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases.

Blair et al (2020) Intracranial hemodynamic relationships in patients with cerebral small vessel disease

Asanad et al (2020) Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline

Montagne et al (2020) APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Brinker et al (2020) Focused Ultrasound Platform for Investigating Therapeutic Neuromodulation Across the Human Hippocampus



Wardlaw et al (2020) Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease

Rachmadi et al (2020) Automatic Spatial Estimation of White Matter Hyperintensities Evolution in Brain MRI using Disease Evolution Predictor Deep Neural Networks

Sweeney et al (2020) A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid

Montagne et al (2020) APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

Habriat et al (2020)  CADASIL: yesterday, today, tomorrow

Nelson et al (2020) Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo



Blair et. al. (2020) Cerebral small vessel disease: Potential interventions for prevention and treatment; Chapter available in book Stroke in the Older Person

Montagne et al. (2020) APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction?

Reeves et al. (2020) Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus

Wardlaw et al (2020) Perivascular spaces in the brain: anatomy, physiology and pathology

Mestre et al (2020) Cerebrospinal fluid influx drives acute ischemic tissue swelling

Ratelade et al (2020) Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage



Hamilton et al. (2020) Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD

Wardlaw et al. (2020) Perivascular spaces in the brain: anatomy, physiology and pathology

Kisler et al. (2020) Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling

Bernal et al. (2020) Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease

Koundal et al. (2020) Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

Koundal et al. (2020) Publisher Correction: Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System



Whitney et. al. (2020). White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed

Shi et al. (2020) Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow.

Koundal et. al. (2020) Supplementary Information for “Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System”.

Aribisala et. al. (2020) Sleep and brain morphological changes in the eighth decade of life

Mestre et al. (2020) Cerebrospinal fluid influx drives acute ischemic tissue swelling

Valdés Hernández et al. (2020) The striatum, the hippocampus, and short-term memory binding: Volumetric analysis of the subcortical grey matter's role in mild cognitive impairment

Ballerini et al (2020). Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936




Ballerini et. al. (2019) Computational quantification of brain perivascular space morphologies: associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936: Perivascular spaces associations

Tianye et. al. (2019) Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Robertson et al. (2019) Cerebrovascular Pulsatility During Rest and Exercise Reflects Hemodynamic Impairment in Stroke and Cerebral Small Vessel Disease

Wardlaw, et. al. (2019). Perivascular Spaces in the Brain: Anatomy, Physiology, and Contributions to Pathology of Brain Diseases

Appleton et al. (2019) Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke

Montagne et al. (2019) Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment

Zhang et al. (2019) Cerebral oxygenation during locomotion is modulated by respiration



Appleton et.al. (2019) Imaging markers of small vessel disease and 'brain frailty' and outcomes in acute stroke

Bernal et al. (2019) Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease

Gattringer et.al. (2019) Predictors of Lesion Cavitation After Recent Small Subcortical Stroke

Habote et.al. (2019) Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments 

Valdés Hernández et. al. (2019) Brain Network Measures and Spatial Lesion Distribution in a Sample of 47 Patients with Systemic Lupus Erythematosus (SLE)

Shukuru & Valdés Hernández (2019) Systematic Review of the Literature on Definitions and Characterisation of MS Lesions

El-Tawil et. al. (2019) Observer Agreement on Computed Tomography Perfusion Imaging in Acute Ischemic Stroke

Rajani et al. (2019) Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL



Babos et. al. (2019) Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming

de Guio et. al. (2019) Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative

Satizabal et.al. (2019) Genetic architecture of subcortical brain structures in 38,851 individuals



Meng et. al. (2019) Glymphatics Visualization afterFocused Ultrasound-InducedBlood–Brain Barrier Openingin Humans

Hachinski et al. (2019) Preventing dementia by preventing stroke: The Berlin Manifesto.

Atwi et al. (2019) Cardiac-Related Pulsatility in the Insula Is Directly Associated With Middle Cerebral Artery Pulsatility Index




Hachinski et al. (2019) Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto.

Joutel A (2019) Prospects for Diminishing the Impact of Nonamyloid Small-Vessel Diseases of the Brain

Mortensen et. al. (2019) Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

Roche et. al. (2019) In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation.



Appleton et.al. (2019) Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial

Aribisala et al. (2019) Sleep and brain morphological changes in the eighth decade of life

Harris et. al. (2019) Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

Hachinski et al. (2019) Preventing dementia by preventing stroke: The Berlin Manifesto.

Hillary et. al. (2019) An epigenetic predictor of death captures multi-modal measures of brain health

Muñoz Maniega et.al. (2019) Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

Sweeney et. al. (2019) In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

Wardlaw et. al. (2019) Small vessel disease: mechanisms and clinical implications

Shi et al. (2019) Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons

Nikolakopoulou et al. (2019) Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss



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Ma et al. (2018). Mol Neurodegener. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.

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Alloza et al. (2018) Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study.

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Sapkota et al. (2018) Alzheimers Res Ther  Clinical dementia severity associated with ventricular size is differentially moderated by cognitive reserve in men and women.

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Madru et al. (2018) Cancer Biother Radiopharm. Simultaneous Preclinical Positron Emission Tomography-Magnetic Resonance Imaging Study of Lymphatic Drainage of Chelator-Free 64Cu-Labeled Nanoparticles.

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Sweeney and Zlokovic (2018). Nature News and Views. 560(7717): 172-174. A lymphatic waste-disposal system implicated in Alzheimer's disease. PMID: 30076374

Zukotynski et al. (2018). AJR Am J Roentgenol. 211(2):246-259. PET/CT of Dementia. PMID: 29949415

Gibson et al. (2018) Post-mortem magnetic resonance imaging in patients with suspected prion disease: Pathological confirmation, sensitivity, specificity and observer reliability. A national registry.



Lipsman et al. (2018) Nat commun. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound.

Aalling et al. (2018). Curr Neurol Neurosci Rep 18(9):57. Cerebral Metabolic Changes During Sleep. PMID: 30014344

Backhouse et al. (2018) PLoS One. 13(7):e0200525. Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis. PMID: 30011299

Benveniste et al. (2018). Genontology 11:1-14. The glymphatic system and waste clearance with brain aging. PMID: 29996134

Freedman et al. (2018) Alzheimers Res Ther 10(1):65. The Toronto Cognitive Assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment. PMID: 30021658

Griffin et al. (2018) Blood. 132(2):159-169. Activated protein C, protease activated receptor 1, and neuroprotection. PMID: 29866816

Jian et al (2018) Stroke. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. PMID: 30002152

Rajani et al. (2018) Science translational medicine. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Access here

Wardlaw (2018) Stroke. 49(7):1770-1775. William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable. PMID: 29895535

Wiseman et al. (2018) Lupus. 27(8):1329-1337. Cognitive function, disease burden and the structural connectome in systemic lupus erythematosus. PMID: 29722629

Zellner et al. (2018) CADASIL brain vessels show a HTRA1 loss-of-function profile.



Ida et al. (2018) Br J Anaesth 120(6):1245-1254. Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of harmorrhagic shock. PMID: 29793592

Kisler et al. (2018) Nat Protoc 13(6):1377-1402. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. PMID: 29844521

Lam et al. (2018) Sci Rep 8(1):9480. Variability in stroke motor outcome is explained by structural and functional integrity of the motor system. PMID: 29930399

Pottier et al. (2018) Lancet Neurol. 17(6):548-558. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration adn GRN mutations: a genome-wide association study. PMID: 2972492



Bernhardt et al. (2018) Stroke. 49(5):e174-199. Advances in Stroke 2017. PMID: 29669874

Brown et al. (2018) Cardiovasc Res. Understanding the role of the perivascular space in cerebral small vessel disease. PMID: 29726891

Cox et al. (2018) Neurobiol of Aging. Longitudinal serum S100β and brain ageing in the Lothian Birth Cohort 1936. 

Fujioka et al. (2018) Ann N Y Acad Sci. The effects of music-supported therapy on motor, cognitive, and psychosocial functions in chronic stroke. PMID: 29797585

Loos et al. (2018) Stroke. 49(5):1183-1188. Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging. PMID: 29567763

Saeed et al. (2018) Alzheimers Dement. APOE-ε4 associates with hippocampal volume, learning, and memort across the spectrum of Alzheimer's disease and dementia with Lewy bodies. PMID: 29782824 

Wong et al. (2018) Int J Geriatr Psychiatry. 33(5):729-734. Converting MMSE to MoCA and MoCA 5-minute protocol in an educationally heterogeneous sample with stroke or transient ischemic attack. PMID: 29292529

Xavier et al. (2018) J Vis Exp. Cannula Implantation into the Cisterna Magna of Rodents. PMID: 29889209



Bailey et al. (2018) Clin Sci (Lond). Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. PMID: 29632138

Dawe et al. (2018) J Gerontol A Biol Sci Med Sci. 73(5):636-642. Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults. PMID: 28957994

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Lewis et al. (2018). Neuroimage. 176:22-28. Widespread associations between trait conscientiousness and thickness of brain cortical regions. PMID: 29665419

Makaryus et al. (2018) Anesthesiology. Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain. PMID: 29688900

Ratelade et al. (2018) J Pathol. 244(4):408-420. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. PMID: 29266233

Shokri-Kojori et al. (2018) Proc Natl Acad Sci USA 115(17):4483-4488. β-Amyloid accumulation in the human brain after one night of sleep deprivation. PMID: 29632177



Berezuk et al. (2018) Int J Geriatr Psychiatry. 33(3):517-522. Managing money matters: Managing finances is associated with functional independence in MCI. PMID: 29076183

Ferguson et al. (2018) J Stroke Cerebrovasc Dis. Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging. PMID: 29576397

Makin et al. (2017) European Stroke Journal. The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke. Access here

McGrory et al. (2018) Transl Vis Sci Technol. 7(2):12. Towards Standardization of Quantitative Retinal Vascular Parameters: Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936. PMID: 29600120

Montagne et al. (2018) Nat Med. 24(3):326-337Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. PMID: 29400711

Rodrigues et al. (2018) Lancet Neurol. 17(3):232-240. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. PMID: 29331631

Skrobot et al. (2018) Alzheimers Dement. 14(3):280-292. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. PMID: 29055812

Sweeney et al. (2018) Nat Rev Neurol. 14(3):133-150. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. PMID: 29377008

Wilcox et al. (2018) Intern Med J. Sleep on the ward in intensive care unit survivors: a case series of polysomnography. PMID: 29521453



Ballerini et al. (2018) Sci Rep. 8(1):2132. Perivascular spaces segmentation in brain MRI using optimal 3D filtering. PMID: 29391404

Desmarais et al. (2018). Int Psychogeriatr. 30(2):197-207. Social inappropriateness in neurodegenerative disorders. PMID: 28689508

Jaswal et al. (2018) Neurobiol Aging. 66:23-31. Reduced substantia innominata volume mediates contributions of microvascular and macrovascular disease to cognitive deficits in Alzheimer's disease. PMID: 29505952

Lundgaard et al. (2018) Sci Rep. 8(1):2246. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. PMID: 29396480

Mortby et al. (2018) Int Psychogeriatr. 30(2):171-175. Dementia clinical trial implications of mild behavioral impairment. PMID: 29448970

Ritchie et al. (2018). Neurobiol Aging. 62:146-158. Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume. PMID: 29149632

Sajic et al. (2018) J Neuroinflammation. 15(1):61. Mitochondrial damage and "plugging" of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation. PMID: 29486771

Santiago et al. (2018) Int J Geriatr Psychiatry. 33(2):279-287. Subcortical hyperintensities in the cholinergic system are associated with improvements in executive function in older adults with coronary artery disease undergoing cardiac rehabilitation. PMID: 28474775

Swardfager et al. (2018). Neurology. 90(8):e673-682. The effect of white matter hyperintensities on verbal memory: Mediation by temporal lobe atrophy. PMID: 29374101

Thrippleton et al.(2018) Int J Stroke. 13(2):195-206. Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing. PMID: 28933655

Wiseman et al. (2018). Hum Brain Mapp. 39(2):622-632. Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age. PMID: 29139161



Anblagan et al. (2018) Brain Behav. 8(2):e00838. Coupled changes in hippocampal structure and cognitive ability in later life. PMID: 29484252

Arba et al. (2018) Int J Stroke. 13(1):47-56. Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack. PMID: 27543501

Cox et al. (2018) Brain Struct Funct. 223(1):509-518. Brain cortical characteristics of lifetime cognitive ageing. PMID: 28879544

Dickie et al. (2018) Int J Stroke. The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury. PMID: 29672236

Harper et al. (2018) J Int Med Res. Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology. PMID: 29578354

Lam et al. (2018) J Neurol Sci. 384:21-29. Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke. PMID: 29249372

Middleton et al. (2018) BMC Geriatr. 18(1):27. Centre- versus home-based exercise among people with mci and mild dementia: study protocol for a randomized parallel-group trial. PMID: 29370756 

Mutsaerts et al. (2018) J Magn Reson Imaging. 47(1):131-140. Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI). PMID: 28480617

Pinter et al. (2018) Aging 10(1):144-153. Predictors of gait speed and its change over three years in community-dwelling older people. PMID: 29356686

Pinter et al. (2018) J Cereb Blood Flow Metab. Longitudinal MRI dynamics of recent small subcortical infarcts and possible predictors. PMID: 29737904

Plog and Nedergaard (2018) Ann Rev Pathol 13:379-394. The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future. PMID: 29195051

Russin et al. (2018) J Cereb Blood Flow Metab. Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. PMID: 29611451

Sandset et al. (2018) Int J Stroke.  Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3.

Shi et al. (2018) Clin Sci (Lond). 132(1):157-171. Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review. PMID: 29229867

Smith et al. (2018) Sci Signal. 11(515). Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions. PMID: 29382785

Sun et al. (2018) J Affect Disord. 225:599-606. Global grey matter volume in adult bipolar patients with and without lithium treatment: A meta-analysis. PMID: 28886501

Verkhratsky and Nedergaard (2018) Physiol Rev 98(1):239-389. Physiology of Astroglia. PMID: 29351512

von Holstein-Rathlou et al. (2018) Neurosci Lett. 662:253-258. Voluntary running enhances glymphatic influx in awake behaving, young mice. PMID: 29079431




Benveniste et al. (2017) Anesthesiology 127(6):976-988. Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane. PMID: 28938276

DiNuzzo and Nedergaard (2017) Curr Opin Neurobiol. 47:65-72. Brain energetics during the sleep-wake cycle.PMID: 29024871

Sohail et al. (2017) Mov Disord. 32(12):1729-1737. Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease. PMID: 29082554

Thrippleton et al. (2017) PLoS One. 12(12):e0189872. Variance components associated with long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T. PMID: 29287066



Arba et al. (2017). Neurology. 89(21):2143-2150. Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke. PMID: 29070665

Desai and Smith (2017) F100Res. 6:1973. Experimental autoimmune encephalomyelitis from a tissue energy perspective. PMID: 29167741

Gibson et al. (2017) Wellcome Open Res 2:114. Impact of detecting potentially serious incidental findings during multi-modal imaging. PMID: 30009267

Montagne et al. (2017) J Exp Med. 214(11):3151-3169. Alzheimer's disease: A matter of blood-brain barrier dysfunction? PMID: 29061693

Ritchie et al. (2017). Brain Struct Funct. 222(8):3477-3490. Risk and protective factors for structural brain ageing in the eighth decade of life. PMID: 28424895

Swardfager et al. (2017) Neurobiol Aging. Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease. PMID: 28756941



Abbott et al. (2017) Front Neurol. 8:537. Optimizing the Definitions of Stroke, Transient Ischemic Attack, and Infarction for Research and Application in Clinical Practice. PMID: 29104559

Duncombe et al. (2017) Neuropathol Appl Neurobiol 43(6):477-491. Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis. PMID: 28039950

MacPherson et al. (2017) Cortex. 95:92-103. Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults. PMID: 28865241

Martinez Sosa and Smith (2017). Clin Sci (Lond). 131(20):2503-2524. Understanding a role for hypoxia in lesion formation and location in the deep and periventricular white matter in small vessel disease and multiple sclerosis. PMID: 29026001

Patel et al. (2017) Neurol Res. 39(10):910-917. Chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis causes selective recognition impairment in adult mice. PMID: 28828966

Roseborough et al. (2017) Alzheimers Dement. 13(10):1154-1167. Associations between amyloid β and white matter hyperintensities: A systematic review. PMID: 28322203



Amar et al. (2017) Neuropharmacology. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. PMID: 28923278

Boulos et al. (2017) Sleep Med. 37:135-140. Restless legs syndrome after high-risk TIA and minor stroke: association with reduced quality of life. PMID: 28899525

Bowles et al. (2017) Neuroimage. Brain lesion segmentation through image synthesis and outlier detection. Access here

Danso et al. (2017) MAPPING: MAnagement and Processing of Images for Population ImagiNG (Fronteirs eBook). Developing an Integrated Image Bank and Metadata for Large-scale Research in Cerebrovascular Disease: Our Experience from the Stroke Image Bank Project. Download here

Dickie et al. (2017) MAPPING: MAnagement and Processing of Images for Population ImagiNG (Fronteirs eBook). 5 Whole Brain Magnetic Resonance Image Atlases: A Systematic Review of Existing Atlases and Caveats for Use in Population Imaging. Download here

Lin and Black (2017) Otol Neurotol. 38(8):e237-239. Linking Deafness and Dementia: Challenges and Opportunities.PMID: 28806332

Loveau et al. (2017) J Clin Invest 127(9):3210-3219. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. PMID: 28862640 

Makin et al. (2017) J Stroke Cerebrovasc Dis. Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review. PMID: 28889932

Mutsaerts et al. (2017) J Cereb Blood Flow Metab. 37(9):3184-3192. The spatial coefficient of variation in arterial spin labeling cerebral blood flow images. PMID: 28058975

Oberheim Bush and Nedergaard (2017). Neurochem Res. 42(9):2577-2587. Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain? PMID: 28822066

Wardlaw et al. (2017) Neurology 89(10):1003-1010. White matter hyperintensity reduction and outcomes after minor stroke. PMID: 28794252



Callahan et al. (2017) Front Aging Neurosci. 9:260. Adult ADHD: Risk Factor for Dementia or Phenotypic Mimic? PMID: 28824421

Guo et al. (2017) Clin Interv Aging. 12:1251-1270. MRI assessment of whole-brain structural changes in aging. PMID: 28848333

Mestre et al. (2017) Clin Sci 131(17):2257-2274 Perivascular spaces, glymphatic dysfunction, and small vessel disease. PMID: 28798076

Moody et al. (2017) Front Neurosci. 11:467. Maximizing the Potential of Longitudinal Cohorts for Research in Neurodegenerative Diseases: A Community Perspective. PMID: 28912672

Nelson et al. (2017) Proc Natl Acad Sci USA. 114(33):8681-8682. Role of clusterin in the brain vascular clearance of amyloid-ß. PMID: 28765369

Valdes Hernandez et al. (2017) Neuroradiology. Metric to quantify white matter damage on brain magnetic resonance images. PMID: 28815362

Wardlaw et al. (2017) J Cereb Blood Flow Metab 37(8):3042-3052 Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study. PMID: 28155579

Windrem et al. (2017) Cell Stem Cell. 21(2):195-208Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia. PMID: 28736215



Arba et al. (2017) Journal of Stroke and Cerebrovascular Diseases 26(7):1506-1513. Cerebral White Matter Hypoperfusion Increases with Small Vessel Disease Burden. Data from the Third International Stroke Trial. PMID: 28314624

Arba et al. (2017) Acta Neurol Scna. 136(1):72-77. Small vessel disease and clinical outcomes after IV rt-PA treatment. PMID: 28233290

Blair et al. (2017) Current Treatment Options in Cardiovascular Medicine 19(7):56. Advanced Neuroimaging of Cerebral Small Vessel Disease. PMID: 28620783

Cameron et al. (2017) Prog Retin Eye Res 59:131-157. Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease. PMID: 28457789

Kisler et al. (2017) Nat Rev Neurosci. 18(7):419-434. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. PMID: 28515434

Mcgrory et al. (2017) Br J Opthalmol. 101(7):993-998. Retinal microvascular network geometry and cognitive abilities in community-dwelling older people: The Lothian Birth Cohort 1936 study. PMID: 28400371

McHutchison et al. (2017) Epidemiology 28(4):608-618. Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life: A Meta-analysis. PMID: 28410350   A video explaining this research can be accessed here

Nestor et al. (2017) Alzheimers Dement 13(7):749-760. Small vessel disease is linked to disrupted structural network covariance in Alzheimer's disease. PMID: 28137552

Netto et al. (2017) Neurosurgery. Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol. PMID: 28973554

Shirzadi et al. (2017) J Magn Reson Imaging. Enhancement of automated blood flow estimates (ENABLE) from arterial spin-labeled MRI. PMID: 28681479

Valdés Hernández et al. (2017) Front. Neurol. Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity. Access here

van Veluw et al. (2017) Lancet Neurology. Detection, risk factors and functional consequences of cerebral microinfarcts. PMID: 28716371

Wilcox et al. (2017) BMJ open. 7(7):e015600. A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study. PMID: 28710215

Zhao and Zlokovic (2017) Cell. Res. 27(7):849-850. Remote control of BBB: A tale of exosomes and microRNA. PMID: 28674430



Cronin et al. (2017). Alz Dementia. 13(6):689-700. Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. PMID: 27883893

Edwards et al. (2017) J Alzheimers Dis 59(3):1113-1122. Antihypertensive Treatment is associated with MRI-Derived Markers of Neurodegeneration and Impaired Cognition: A Propensity-Weighted Cohort Study. PMID: 28731439

González-Castro et al. (2017) Clin Sci 131(13):1465-1481. Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance PMID: 28468952

Kjaerby et al. (2017) Neurochem Res. 42(6):1810-1822. Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function? PMID: 28210958

Lee et al. (2017) Magn Reson Med. Quantative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. PMID: 28627037

Lundgaard et al. (2017) J Cereb Blood Flow Metab 37(6):2112-2124. Glymphatic clearance controls state-dependent changes in brain lactate concentration. PMID: 27481936

Robertson et al. (2017) AJNR Am J Neuroradiol. Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity. PMID: 28619834

Shenkin et al. (2017) Neuroimage 153:399-409. Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group. PMID: 28232121

Stamenova et al. (2017) Cortex. 91:316-326. The effect of focal cortical frontal and posterior lesions on recollection and familiarity in recognition memory. PMID: 28499557

Wardlaw et al. (2017) Alzheimer's and Dementia 13(6):634-643. Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study. Access here



Lam et al. (2017) Alzheimers Dement. 13(5):520-530. Characterizing familial corticobasal syndrome due to Alzheimer's disease pathology and PSEN1 mutations.PMID: 27743520

Lin et al. (2017) Laryngoscope. 127 Suppl 1:S4-S11. Development of cognitive screening test for the severely hearing impaired: Hearing-impaired MoCA. PMID: 28409842

Meng et al. (2017) Ann Neurol. 81(5):611-617. Focused ultrasound as a novel strategy for Alzheimer disease therapeutics. PMID: 28395123

Montero-Odasso et al. (2017) J Alz Dis. 59(2):707-721. Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). PMID: 28671116

Mutsaerts et al. (2017) J Magn reson Imaging. Comparison of arterial spin labeling registration strategies in the multi-centre GENetic frontotemporal dementia initiative (GENFI). PMID: 28480617

Ochocinska et al. (2017) Fluids Barriers CNS. 14(1):12. NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. PMID: 28457227

Ratner et al. (2017) Neuroimage 152:530-537. Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport. PMID: 28323163

Smith et al. (2017). J Am Heart Assoc. 6(5). Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment. PMID: 28476873

Wiseman et al. (2017) Lupus 26(6):588-597. Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study and meta-analysis. PMID: 27687026



Cole et al. (2017) Mol Psychiatry. Brain age predicts mortality. PMID: 28439103

Cox et al. (2017) Psychoneuroendocrinology 78:151-158. Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men. PMID: 28199858

Jiang et al. (2017) J Cereb Blood Flow Metab. 37(4):1326-1337. Impairment of the glymphatic system after diabetes. PMID: 27306755

Joutel and Chabriat (2017) Clin Sci. 131(8):635-651. Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms. PMID: 28351960

Keith et al. (2017) J Neuropathol Exp Neurol. 76(4):299-312. Collagenosis of the Deep Medullary Veins: An Underrecognised Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction? PMID: 28431180

Lim et al. (2017) Nat Commun. 8:14931. Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease. PMID: 28368004

McKenzie et al. (2017) Sci Rep. 7:45567. Validation of a smartphone-based EEG among people with epilepsy: A prospective study. PMID: 28367974

Nikolakopoulou et al. (2017) PLoS One Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signalling. PMID: 28441414

Sun et al. (2017) J Neurosci. 37(17):4493-4507. SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. PMID: 28336567

Valdes Hernandez et al. (2017). Neurobiol Aging. 52:1-11. Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936. PMID: 28104542



Backhouse et al. (2017) Neurology. 88(10):976-984. Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis. PMID: 28188307

Berezuk et al. (2017) J Alz Dis. 58(2):425-434. Functional Reserve: Experience Participating in Instrumental Activities of Daily Living is Associated with Gender and Functional Independence in Mild Cognitive Impairment. PMID: 28453478

Boulos et al. (2017) Sleep. 40(3). Periodic Limb Movements and White Matter Hyperintensities in First-Ever Minor Stroke or High-Risk Transient Ischemic Attack. PMID: 28329254

de Leon et al. (2017) J Nucl Med. CSF clearance in Alzheimer Disease measured with dynamic PET. PMID: 28302766

Kisler et al. (2017) Nat Neurosci. 20(3):406-416. Pericyte degeneration leads to neurovascular uncoupling and limites oxygen supply to brain. PMID: 28135240

Marcotte et al. (2017). Dement Geriatr Cogn Dis Extra. 7(1):52-73. White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia. PMID: 28611820

Pettersen et al. (2017) Neurology 88(11):1077-1080. CADASIL accelerated by acute hypotension: Arterial and venous contribution to leukoaraiosis. PMID: 28202707

Wang et al. (2017) J Neurosci. 37(11):2870-2877. Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts. PMID: 28188218



Benveniste et al. (2017) J Clin Invest. 127(2):447-449. Seeing how we smell. PMID: 28112677

Cotrina et al. (2017) Neuroscience 343:483-494. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. PMID: 28003156

Chappell et al. (2017) Trials 18(1):78. Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study. PMID: 28222778

Mair et al. (2017) Stroke. 48(2):353-360. Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke. PMID: 28008093

Muñoz Maniega et al. (2017) J Cereb Blood Flow Metab 37(2):644-656 Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease. PMID: 26933133

Van der Putten et al. (2017) Physiol Meas. 38(2):205-218. A multispectral microscope for in vivo oximetry of rat dorsal spinal cord vasculature. PMID: 28001129



Benveniste et al. (2017) Neuroscientist. The Glymphatic Pathway. PMID: 28466758

Blair et al. (2017) Int J Stroke. Preventing cognitive decline and dementia from cerebral small vessel disease: the laci-1 trial. Protocol and statistical analysis plan f a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination. PMID: 28906205

Boulos et al. (2017) J Stroke Cerebrovasc Dis. 26(1):143-149. Unattended Hospital and Home Sleep Apnea Testing Following Cerebrovascular Events. PMID: 27717683

Dickie et al. (2017) Int J Stroke. Blood pressure variability and leukoaraiosis in acute ischemic stroke. PMID: 28872448

Job et al. (2017) Neuroimage. 144(PtB):299-304. A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS). PMID: 26794641

Liu et al.,(2017) J Cereb Blood Flow Metab. Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. PMID: 29192539

Loos et al. (2017) Int J Stroke. The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke. PMID: 28906203

Pinter et al. (2017) Sci Rep. Impact of small vessel disease in the brain on gait and balance. PMID: 28134332

Rungta et al. (2017) Nat Commun. Light controls cerebral blood flow in naive animals. PMID: 28139643

Swardfager et al. (2017) Alzheimers Dement 7:56-60. Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report. PMID: 28275700

Thrippleton et al. (2017) Int J Stroke. Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing. PMID: 28933655