Professor William van Nostrand

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Professor William van Nostrand is the Co-Director for the George & Anne Ryan Institute for Neuroscience, and Herrmann Professor of Neuroscience at the Department of Biomedical and Pharmaceutical Sciences, The University of Rhode Island.

His research focuses on the pathogenesis of cerebral amyloid angiopathy, cerebral small vessel disease and Alzheimer’s disease using biochemical, molecular, cellular and animal model approaches. To this end, his research groups have generated novel transgenic and knock in rat models of disease that provide new opportunities to investigate these conditions using life-style, imaging and cognitive testing approaches.

Professor van Nostrand has been awarded the National Insitute of Health (NIH) grants for the following research projects:

  • A therapeutic target for cerebral amyloid angiopathy (project period:  9/19-8/21, role: co-PI)
  • Structural Identification and Functional Consequences of Different Amyloid Strains in Alzheimer's Disease (project period:  9/18-5/23, role: co-PI)
  • Cerebral amyloid angiopathy fluid biomarkers evaluation (CAFE) (project period:  7/18-6/23, role: PI)
  • Role of copper in cerebral amyloid angiopathy (project period:  7/16-6/21, role: PI)
  • Characterizing the glymphatic peri-vascular connectome and its disruption in AD (project period:  9/16-8/21, role: co-PI)
  • Understanding the origins of amyloid deposition in cerebral amyloid angiopathy (project period:  7/16-6/21, role: PI)
  • Structural markers for Alzheimer’s disease and cerebral amyloid angiopathy (project period:  8/16-7/21, role: co-PI)

 

Key publications

Davis, J., Xu, F., Hatfield, J., Lee H., Hoos, M.D., Popescu, D., Crooks, E., Kim, R., Smith, S.O., Robinson, J.K., Benveniste, H., and Van Nostrand, W.E. A novel transgenic rat model of robust cerebral microvascular amyloid with prominent vasculopathy. American Journal of Pathology 188:2877-2889 (2018) PMID 30446159.

Article link: www.sciencedirect.com/science/article/pii/S0002944018304929

Zhu, X., Hatfield, J., Sullivan, J.K., Xu, F., and Van Nostrand, W.E. Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy. Journal of Neuroinflammation 17:78 (2020) PMID 32127016.

Article link: jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01755-y

 

Related links

Professor William van Nostrand profile at The University of Rhode Island

Institutions: 
Yale University