Home » Network Publications

Publications from network members since the project began

 

April 2019

Blair et al. (2019) EClinicalMedicine. Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial

Thrippleton et al. (2019). Alzheimer's and Dementia. Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendation

Mutsaerts et al. (2019). Brain. Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study.

Desmarais et al. (2019) J of Neurology, Neurosurgery& Psychiatry. Therapeutic trial design for frontotemporal dementia and related disorders.

Benveniste et al. (2019) Anesth Analg. Glymphatic System Function in Relation to Anesthesia and Sleep States.

Koundal et al. (2019). Neuroscience. Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI.

Zeng et al. (2019). Cell Rep. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.

Lindekleiv et al. (2019). Stroke. Percutaneous Vascular Interventions Versus Intravenous Thrombolytic Treatment for Acute Ischemic Stroke.

McHutchison et al. (2019) J of Neurology, Neurosurgery& Psychiatry. Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke.

Bath et al. (2019). Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial.

Humphreys et al. (2019) A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology.

Mishra et al. (2019) Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects.

Weaver et al. (2019) The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

March 2019

Anderson  et al. (2019) Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial.

Atwi et al. (2019) NMR Biomed. BOLD-based cerebrovascular reactivity vascular transfer function isolates amplitude and timing responses to better characterize cerebral small vessel disease.

Boido et al. (2019) Nat Commun Mesoscopic and microscopic imaging of sensory responses in the same animal.

Munk et al. (2019) Cell Rep. PDGF-B Is Required for Development of the Glymphatic System.

Ortiz-Ramon et al. (2019). Comput Med Imaging Graph. Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images.

Valdes Hernandez et al. (2019) Int J Mol Sci. Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke.

Cox et al. (2019) Eur Heart J. Associations between vascular risk factors and brain MRI indices in UK Biobank.

Fetit et al. (2019) Sci Rep. A multimodal approach to cardiovascular risk stratification in patients with type 2 diabetes incorporating retinal, genomic and clinical features.

Georgakis et al. (2019) Neurology. WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis.

February 2019

Sun et al. (2019)Lithium Carbonate in a Poststroke Population: Exploratory Analyses of Neuroanatomical and Cognitive Outcomes.

Duchesne et al. (2019)  The Canadian Dementia Imaging Protocol: Harmonizing National Cohorts.

Auriat et al. (2019).  The Impact of Covert Lacunar Infarcts and White Matter Hyperintensities on Cognitive and Motor Outcomes After Stroke.

Rungta et al. (2019) Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia.

Cai et al. (2019).  Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.

Sagare et al. (2019).   Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits.

Lazic et al. (2019)3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice.

Francis et al. (2019) Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis.

Thrippleton et al. (2019).  MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease.

Smith et al. (2019)  Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.

Hablitz et al (2019)  Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.

Appleton et al. (2019) Effect of Glyceryl Trinitrate on Hemodynamics in Acute Stroke.

January 2019

Sweeney et al. (2019). Alzheimers Dement. Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney et al. (2019). Physiol Rev. Blood-Brain Barrier: From Physiology to Disease and Back.

Demiral et al. (2019) Neuroimage.  Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system?

Ramos et al. (2019) Methods Mol Biol. Cisterna Magna Injection in Rats to Study Glymphatic Function.

Rehm et al. (2019) Alzheimers Res Ther. Alcohol use and dementia: a systematic scoping review. PMID: 30611304

Dey et al. (2019). Neurobiol Aging. Cognitive hereterogeneity among community-dwelling older adults with cerebral small vessel disease. PMID: 30875655

Mikhael et al. (2019) Manually-parcellated gyral data accounting for all known anatomical variability.

Ulas et al. (2019) Convolutional Neural Networks for Direct Inference of Pharmacokinetic Parameters: Application to Stroke Dynamic Contrast-Enhanced MRI.

Chauhan et al. (2019) Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Wiseman et al. (2019).  Longitudinal multi-centre brain imaging studies: guidelines and practical tips for accurate and reproducible imaging endpoints and data sharing.

Wardlaw and Bath (2019) Stroke research in 2018: extended time windows, refined benefit, and lifestyle prevention targets.

December 2018

Davis et al. (2018). Am J Pathol. A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.

Mestre et al. (2018) Elife. Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Plog et al. (2018) JCI Insight. Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Franceschini et al. (2018) GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

November 2018

Yu et al. (2018) Transl Stroke Res. Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment.

Malik et al. (2018) Neurorehabil Neural Repair. Subcortical Brain Involvement Is Associated With Impaired Performance on the Psychomotor Vigilance Task After Minor Stroke.

Bergeron et al. (2018). Ann Neurol. Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.

Mestre et al. (2018) Nat Commun. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Rasmussen, Mestre and Nedergaard (2018). Lancet Neurology. 17(11):1016-1024. The glymphatic pathway in neurological disorders. Access here

Godolphin et al. (2018) Central masked adjudication of stroke diagnosis at trial entry offered no advantage over diagnosis by local clinicians: Secondary analysis and simulation.

Gibson et al. (2018) Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis.

Mair et al. (2018) Effect of IV alteplase on the ischemic brain lesion at 24-48 hours after ischemic stroke.

October 2018

Ma et al. (2018). Mol Neurodegener. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.

Sweeney et al. (2018) Nat Neurosci. The role of brain vasculature in neurodegenerative disorders.

Lindekleiv et al. (2018) Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke.

Shi et al. (2018) Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow.

Alloza et al. (2018) Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study.

Alhusaini et al. (2018) Association between carotid atheroma and cerebral cortex structure at age 73 years.

September 2018

Sapkota et al. (2018) Alzheimers Res Ther  Clinical dementia severity associated with ventricular size is differentially moderated by cognitive reserve in men and women.

Lim et al. (2018) PLoS Med. Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.

Elkin et al. (2018) Med Image Comput Comput Assist Interv. GlymphVIS: Visualizing Glymphatic Transport Pathways Using Regularized Optimal Transport.

Voljinovic et al. (2018) Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.

August 2018

Madru et al. (2018) Cancer Biother Radiopharm. Simultaneous Preclinical Positron Emission Tomography-Magnetic Resonance Imaging Study of Lymphatic Drainage of Chelator-Free 64Cu-Labeled Nanoparticles.

Pelligrini et al. (2018) Alzheimers Dement. Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review.

Sweeney and Zlokovic (2018). Nature News and Views. 560(7717): 172-174. A lymphatic waste-disposal system implicated in Alzheimer's disease. PMID: 30076374

Zukotynski et al. (2018). AJR Am J Roentgenol. 211(2):246-259. PET/CT of Dementia. PMID: 29949415

Gibson et al. (2018) Post-mortem magnetic resonance imaging in patients with suspected prion disease: Pathological confirmation, sensitivity, specificity and observer reliability. A national registry.

July 2018

Lipsman et al. (2018) Nat commun. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound.

Aalling et al. (2018). Curr Neurol Neurosci Rep 18(9):57. Cerebral Metabolic Changes During Sleep. PMID: 30014344

Backhouse et al. (2018) PLoS One. 13(7):e0200525. Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis. PMID: 30011299

Benveniste et al. (2018). Genontology 11:1-14. The glymphatic system and waste clearance with brain aging. PMID: 29996134

Freedman et al. (2018) Alzheimers Res Ther 10(1):65. The Toronto Cognitive Assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment. PMID: 30021658

Griffin et al. (2018) Blood. 132(2):159-169. Activated protein C, protease activated receptor 1, and neuroprotection. PMID: 29866816

Jian et al (2018) Stroke. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. PMID: 30002152

Rajani et al. (2018) Science translational medicine. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Access here

Wardlaw (2018) Stroke. 49(7):1770-1775. William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable. PMID: 29895535

Wiseman et al. (2018) Lupus. 27(8):1329-1337. Cognitive function, disease burden and the structural connectome in systemic lupus erythematosus. PMID: 29722629

Zellner et al. (2018) CADASIL brain vessels show a HTRA1 loss-of-function profile.

June 2018

Ida et al. (2018) Br J Anaesth 120(6):1245-1254. Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of harmorrhagic shock. PMID: 29793592

Kisler et al. (2018) Nat Protoc 13(6):1377-1402. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. PMID: 29844521

Lam et al. (2018) Sci Rep 8(1):9480. Variability in stroke motor outcome is explained by structural and functional integrity of the motor system. PMID: 29930399

Pottier et al. (2018) Lancet Neurol. 17(6):548-558. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration adn GRN mutations: a genome-wide association study. PMID: 2972492

May 2018

Bernhardt et al. (2018) Stroke. 49(5):e174-199. Advances in Stroke 2017. PMID: 29669874

Brown et al. (2018) Cardiovasc Res. Understanding the role of the perivascular space in cerebral small vessel disease. PMID: 29726891

Cox et al. (2018) Neurobiol of Aging. Longitudinal serum S100β and brain ageing in the Lothian Birth Cohort 1936. 

Fujioka et al. (2018) Ann N Y Acad Sci. The effects of music-supported therapy on motor, cognitive, and psychosocial functions in chronic stroke. PMID: 29797585

Loos et al. (2018) Stroke. 49(5):1183-1188. Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging. PMID: 29567763

Saeed et al. (2018) Alzheimers Dement. APOE-ε4 associates with hippocampal volume, learning, and memort across the spectrum of Alzheimer's disease and dementia with Lewy bodies. PMID: 29782824 

Wong et al. (2018) Int J Geriatr Psychiatry. 33(5):729-734. Converting MMSE to MoCA and MoCA 5-minute protocol in an educationally heterogeneous sample with stroke or transient ischemic attack. PMID: 29292529

Xavier et al. (2018) J Vis Exp. Cannula Implantation into the Cisterna Magna of Rodents. PMID: 29889209

April 2018

Bailey et al. (2018) Clin Sci (Lond). Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. PMID: 29632138

Dawe et al. (2018) J Gerontol A Biol Sci Med Sci. 73(5):636-642. Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults. PMID: 28957994

Horsburgh et al. (2018) Clin Sci (Lond). 132(8):851-868. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. PMID: 29712883

Lewis et al. (2018). Neuroimage. 176:22-28. Widespread associations between trait conscientiousness and thickness of brain cortical regions. PMID: 29665419

Makaryus et al. (2018) Anesthesiology. Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain. PMID: 29688900

Ratelade et al. (2018) J Pathol. 244(4):408-420. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. PMID: 29266233

Shokri-Kojori et al. (2018) Proc Natl Acad Sci USA 115(17):4483-4488. β-Amyloid accumulation in the human brain after one night of sleep deprivation. PMID: 29632177

March 2018

Berezuk et al. (2018) Int J Geriatr Psychiatry. 33(3):517-522. Managing money matters: Managing finances is associated with functional independence in MCI. PMID: 29076183

Ferguson et al. (2018) J Stroke Cerebrovasc Dis. Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging. PMID: 29576397

Makin et al. (2017) European Stroke Journal. The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke. Access here

McGrory et al. (2018) Transl Vis Sci Technol. 7(2):12. Towards Standardization of Quantitative Retinal Vascular Parameters: Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936. PMID: 29600120

Montagne et al. (2018) Nat Med. 24(3):326-337Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. PMID: 29400711

Rodrigues et al. (2018) Lancet Neurol. 17(3):232-240. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. PMID: 29331631

Skrobot et al. (2018) Alzheimers Dement. 14(3):280-292. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. PMID: 29055812

Sweeney et al. (2018) Nat Rev Neurol. 14(3):133-150. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. PMID: 29377008

Wilcox et al. (2018) Intern Med J. Sleep on the ward in intensive care unit survivors: a case series of polysomnography. PMID: 29521453

February 2018

Ballerini et al. (2018) Sci Rep. 8(1):2132. Perivascular spaces segmentation in brain MRI using optimal 3D filtering. PMID: 29391404

Desmarais et al. (2018). Int Psychogeriatr. 30(2):197-207. Social inappropriateness in neurodegenerative disorders. PMID: 28689508

Jaswal et al. (2018) Neurobiol Aging. 66:23-31. Reduced substantia innominata volume mediates contributions of microvascular and macrovascular disease to cognitive deficits in Alzheimer's disease. PMID: 29505952

Lundgaard et al. (2018) Sci Rep. 8(1):2246. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. PMID: 29396480

Mortby et al. (2018) Int Psychogeriatr. 30(2):171-175. Dementia clinical trial implications of mild behavioral impairment. PMID: 29448970

Ritchie et al. (2018). Neurobiol Aging. 62:146-158. Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume. PMID: 29149632

Sajic et al. (2018) J Neuroinflammation. 15(1):61. Mitochondrial damage and "plugging" of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation. PMID: 29486771

Santiago et al. (2018) Int J Geriatr Psychiatry. 33(2):279-287. Subcortical hyperintensities in the cholinergic system are associated with improvements in executive function in older adults with coronary artery disease undergoing cardiac rehabilitation. PMID: 28474775

Swardfager et al. (2018). Neurology. 90(8):e673-682. The effect of white matter hyperintensities on verbal memory: Mediation by temporal lobe atrophy. PMID: 29374101

Thrippleton et al.(2018) Int J Stroke. 13(2):195-206. Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing. PMID: 28933655

Wiseman et al. (2018). Hum Brain Mapp. 39(2):622-632. Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age. PMID: 29139161

January 2018

Anblagan et al. (2018) Brain Behav. 8(2):e00838. Coupled changes in hippocampal structure and cognitive ability in later life. PMID: 29484252

Arba et al. (2018) Int J Stroke. 13(1):47-56. Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack. PMID: 27543501

Cox et al. (2018) Brain Struct Funct. 223(1):509-518. Brain cortical characteristics of lifetime cognitive ageing. PMID: 28879544

Dickie et al. (2018) Int J Stroke. The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury. PMID: 29672236

Harper et al. (2018) J Int Med Res. Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology. PMID: 29578354

Lam et al. (2018) J Neurol Sci. 384:21-29. Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke. PMID: 29249372

Middleton et al. (2018) BMC Geriatr. 18(1):27. Centre- versus home-based exercise among people with mci and mild dementia: study protocol for a randomized parallel-group trial. PMID: 29370756 

Mutsaerts et al. (2018) J Magn Reson Imaging. 47(1):131-140. Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI). PMID: 28480617

Pinter et al. (2018) Aging 10(1):144-153. Predictors of gait speed and its change over three years in community-dwelling older people. PMID: 29356686

Pinter et al. (2018) J Cereb Blood Flow Metab. Longitudinal MRI dynamics of recent small subcortical infarcts and possible predictors. PMID: 29737904

Plog and Nedergaard (2018) Ann Rev Pathol 13:379-394. The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future. PMID: 29195051

Russin et al. (2018) J Cereb Blood Flow Metab. Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. PMID: 29611451

Sandset et al. (2018) Int J Stroke.  Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3.

Shi et al. (2018) Clin Sci (Lond). 132(1):157-171. Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review. PMID: 29229867

Smith et al. (2018) Sci Signal. 11(515). Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions. PMID: 29382785

Sun et al. (2018) J Affect Disord. 225:599-606. Global grey matter volume in adult bipolar patients with and without lithium treatment: A meta-analysis. PMID: 28886501

Verkhratsky and Nedergaard (2018) Physiol Rev 98(1):239-389. Physiology of Astroglia. PMID: 29351512

von Holstein-Rathlou et al. (2018) Neurosci Lett. 662:253-258. Voluntary running enhances glymphatic influx in awake behaving, young mice. PMID: 29079431

December 2017

Benveniste et al. (2017) Anesthesiology 127(6):976-988. Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane. PMID: 28938276

DiNuzzo and Nedergaard (2017) Curr Opin Neurobiol. 47:65-72. Brain energetics during the sleep-wake cycle.PMID: 29024871

Sohail et al. (2017) Mov Disord. 32(12):1729-1737. Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease. PMID: 29082554

Thrippleton et al. (2017) PLoS One. 12(12):e0189872. Variance components associated with long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T. PMID: 29287066

November 2017

Arba et al. (2017). Neurology. 89(21):2143-2150. Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke. PMID: 29070665

Desai and Smith (2017) F100Res. 6:1973. Experimental autoimmune encephalomyelitis from a tissue energy perspective. PMID: 29167741

Gibson et al. (2017) Wellcome Open Res 2:114. Impact of detecting potentially serious incidental findings during multi-modal imaging. PMID: 30009267

Montagne et al. (2017) J Exp Med. 214(11):3151-3169. Alzheimer's disease: A matter of blood-brain barrier dysfunction? PMID: 29061693

Ritchie et al. (2017). Brain Struct Funct. 222(8):3477-3490. Risk and protective factors for structural brain ageing in the eighth decade of life. PMID: 28424895

Swardfager et al. (2017) Neurobiol Aging. Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease. PMID: 28756941

October 2017

Abbott et al. (2017) Front Neurol. 8:537. Optimizing the Definitions of Stroke, Transient Ischemic Attack, and Infarction for Research and Application in Clinical Practice. PMID: 29104559

Duncombe et al. (2017) Neuropathol Appl Neurobiol 43(6):477-491. Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis. PMID: 28039950

MacPherson et al. (2017) Cortex. 95:92-103. Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults. PMID: 28865241

Martinez Sosa and Smith (2017). Clin Sci (Lond). 131(20):2503-2524. Understanding a role for hypoxia in lesion formation and location in the deep and periventricular white matter in small vessel disease and multiple sclerosis. PMID: 29026001

Patel et al. (2017) Neurol Res. 39(10):910-917. Chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis causes selective recognition impairment in adult mice. PMID: 28828966

Roseborough et al. (2017) Alzheimers Dement. 13(10):1154-1167. Associations between amyloid β and white matter hyperintensities: A systematic review. PMID: 28322203

September 2017

Amar et al. (2017) Neuropharmacology. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. PMID: 28923278

Boulos et al. (2017) Sleep Med. 37:135-140. Restless legs syndrome after high-risk TIA and minor stroke: association with reduced quality of life. PMID: 28899525

Bowles et al. (2017) Neuroimage. Brain lesion segmentation through image synthesis and outlier detection. Access here

Danso et al. (2017) MAPPING: MAnagement and Processing of Images for Population ImagiNG (Fronteirs eBook). Developing an Integrated Image Bank and Metadata for Large-scale Research in Cerebrovascular Disease: Our Experience from the Stroke Image Bank Project. Download here

Dickie et al. (2017) MAPPING: MAnagement and Processing of Images for Population ImagiNG (Fronteirs eBook). 5 Whole Brain Magnetic Resonance Image Atlases: A Systematic Review of Existing Atlases and Caveats for Use in Population Imaging. Download here

Lin and Black (2017) Otol Neurotol. 38(8):e237-239. Linking Deafness and Dementia: Challenges and Opportunities.PMID: 28806332

Loveau et al. (2017) J Clin Invest 127(9):3210-3219. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. PMID: 28862640 

Makin et al. (2017) J Stroke Cerebrovasc Dis. Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review. PMID: 28889932

Mutsaerts et al. (2017) J Cereb Blood Flow Metab. 37(9):3184-3192. The spatial coefficient of variation in arterial spin labeling cerebral blood flow images. PMID: 28058975

Oberheim Bush and Nedergaard (2017). Neurochem Res. 42(9):2577-2587. Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain? PMID: 28822066

Wardlaw et al. (2017) Neurology 89(10):1003-1010. White matter hyperintensity reduction and outcomes after minor stroke. PMID: 28794252

August 2017

Callahan et al. (2017) Front Aging Neurosci. 9:260. Adult ADHD: Risk Factor for Dementia or Phenotypic Mimic? PMID: 28824421

Guo et al. (2017) Clin Interv Aging. 12:1251-1270. MRI assessment of whole-brain structural changes in aging. PMID: 28848333

Mestre et al. (2017) Clin Sci 131(17):2257-2274 Perivascular spaces, glymphatic dysfunction, and small vessel disease. PMID: 28798076

Moody et al. (2017) Front Neurosci. 11:467. Maximizing the Potential of Longitudinal Cohorts for Research in Neurodegenerative Diseases: A Community Perspective. PMID: 28912672

Nelson et al. (2017) Proc Natl Acad Sci USA. 114(33):8681-8682. Role of clusterin in the brain vascular clearance of amyloid-ß. PMID: 28765369

Valdes Hernandez et al. (2017) Neuroradiology. Metric to quantify white matter damage on brain magnetic resonance images. PMID: 28815362

Wardlaw et al. (2017) J Cereb Blood Flow Metab 37(8):3042-3052 Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study. PMID: 28155579

Windrem et al. (2017) Cell Stem Cell. 21(2):195-208Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia. PMID: 28736215

July 2017

Arba et al. (2017) Journal of Stroke and Cerebrovascular Diseases 26(7):1506-1513. Cerebral White Matter Hypoperfusion Increases with Small Vessel Disease Burden. Data from the Third International Stroke Trial. PMID: 28314624

Arba et al. (2017) Acta Neurol Scna. 136(1):72-77. Small vessel disease and clinical outcomes after IV rt-PA treatment. PMID: 28233290

Blair et al. (2017) Current Treatment Options in Cardiovascular Medicine 19(7):56. Advanced Neuroimaging of Cerebral Small Vessel Disease. PMID: 28620783

Cameron et al. (2017) Prog Retin Eye Res 59:131-157. Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease. PMID: 28457789

Kisler et al. (2017) Nat Rev Neurosci. 18(7):419-434. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. PMID: 28515434

Mcgrory et al. (2017) Br J Opthalmol. 101(7):993-998. Retinal microvascular network geometry and cognitive abilities in community-dwelling older people: The Lothian Birth Cohort 1936 study. PMID: 28400371

McHutchison et al. (2017) Epidemiology 28(4):608-618. Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life: A Meta-analysis. PMID: 28410350   A video explaining this research can be accessed here

Nestor et al. (2017) Alzheimers Dement 13(7):749-760. Small vessel disease is linked to disrupted structural network covariance in Alzheimer's disease. PMID: 28137552

Netto et al. (2017) Neurosurgery. Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol. PMID: 28973554

Shirzadi et al. (2017) J Magn Reson Imaging. Enhancement of automated blood flow estimates (ENABLE) from arterial spin-labeled MRI. PMID: 28681479

Valdés Hernández et al. (2017) Front. Neurol. Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity. Access here

van Veluw et al. (2017) Lancet Neurology. Detection, risk factors and functional consequences of cerebral microinfarcts. PMID: 28716371

Wilcox et al. (2017) BMJ open. 7(7):e015600. A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study. PMID: 28710215

Zhao and Zlokovic (2017) Cell. Res. 27(7):849-850. Remote control of BBB: A tale of exosomes and microRNA. PMID: 28674430

June 2017

Cronin et al. (2017). Alz Dementia. 13(6):689-700. Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. PMID: 27883893

Edwards et al. (2017) J Alzheimers Dis 59(3):1113-1122. Antihypertensive Treatment is associated with MRI-Derived Markers of Neurodegeneration and Impaired Cognition: A Propensity-Weighted Cohort Study. PMID: 28731439

González-Castro et al. (2017) Clin Sci 131(13):1465-1481. Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance PMID: 28468952

Kjaerby et al. (2017) Neurochem Res. 42(6):1810-1822. Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function? PMID: 28210958

Lee et al. (2017) Magn Reson Med. Quantative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. PMID: 28627037

Lundgaard et al. (2017) J Cereb Blood Flow Metab 37(6):2112-2124. Glymphatic clearance controls state-dependent changes in brain lactate concentration. PMID: 27481936

Robertson et al. (2017) AJNR Am J Neuroradiol. Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity. PMID: 28619834

Shenkin et al. (2017) Neuroimage 153:399-409. Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group. PMID: 28232121

Stamenova et al. (2017) Cortex. 91:316-326. The effect of focal cortical frontal and posterior lesions on recollection and familiarity in recognition memory. PMID: 28499557

Wardlaw et al. (2017) Alzheimer's and Dementia 13(6):634-643. Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study. Access here

May 2017

Lam et al. (2017) Alzheimers Dement. 13(5):520-530. Characterizing familial corticobasal syndrome due to Alzheimer's disease pathology and PSEN1 mutations.PMID: 27743520

Lin et al. (2017) Laryngoscope. 127 Suppl 1:S4-S11. Development of cognitive screening test for the severely hearing impaired: Hearing-impaired MoCA. PMID: 28409842

Meng et al. (2017) Ann Neurol. 81(5):611-617. Focused ultrasound as a novel strategy for Alzheimer disease therapeutics. PMID: 28395123

Montero-Odasso et al. (2017) J Alz Dis. 59(2):707-721. Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). PMID: 28671116

Mutsaerts et al. (2017) J Magn reson Imaging. Comparison of arterial spin labeling registration strategies in the multi-centre GENetic frontotemporal dementia initiative (GENFI). PMID: 28480617

Ochocinska et al. (2017) Fluids Barriers CNS. 14(1):12. NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. PMID: 28457227

Ratner et al. (2017) Neuroimage 152:530-537. Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport. PMID: 28323163

Smith et al. (2017). J Am Heart Assoc. 6(5). Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment. PMID: 28476873

Wiseman et al. (2017) Lupus 26(6):588-597. Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study and meta-analysis. PMID: 27687026

April 2017

Cole et al. (2017) Mol Psychiatry. Brain age predicts mortality. PMID: 28439103

Cox et al. (2017) Psychoneuroendocrinology 78:151-158. Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men. PMID: 28199858

Jiang et al. (2017) J Cereb Blood Flow Metab. 37(4):1326-1337. Impairment of the glymphatic system after diabetes. PMID: 27306755

Joutel and Chabriat (2017) Clin Sci. 131(8):635-651. Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms. PMID: 28351960

Keith et al. (2017) J Neuropathol Exp Neurol. 76(4):299-312. Collagenosis of the Deep Medullary Veins: An Underrecognised Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction? PMID: 28431180

Lim et al. (2017) Nat Commun. 8:14931. Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease. PMID: 28368004

McKenzie et al. (2017) Sci Rep. 7:45567. Validation of a smartphone-based EEG among people with epilepsy: A prospective study. PMID: 28367974

Nikolakopoulou et al. (2017) PLoS One Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signalling. PMID: 28441414

Sun et al. (2017) J Neurosci. 37(17):4493-4507. SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. PMID: 28336567

Valdes Hernandez et al. (2017). Neurobiol Aging. 52:1-11. Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936. PMID: 28104542

March 2017

Backhouse et al. (2017) Neurology. 88(10):976-984. Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis. PMID: 28188307

Berezuk et al. (2017) J Alz Dis. 58(2):425-434. Functional Reserve: Experience Participating in Instrumental Activities of Daily Living is Associated with Gender and Functional Independence in Mild Cognitive Impairment. PMID: 28453478

Boulos et al. (2017) Sleep. 40(3). Periodic Limb Movements and White Matter Hyperintensities in First-Ever Minor Stroke or High-Risk Transient Ischemic Attack. PMID: 28329254

de Leon et al. (2017) J Nucl Med. CSF clearance in Alzheimer Disease measured with dynamic PET. PMID: 28302766

Kisler et al. (2017) Nat Neurosci. 20(3):406-416. Pericyte degeneration leads to neurovascular uncoupling and limites oxygen supply to brain. PMID: 28135240

Marcotte et al. (2017). Dement Geriatr Cogn Dis Extra. 7(1):52-73. White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia. PMID: 28611820

Pettersen et al. (2017) Neurology 88(11):1077-1080. CADASIL accelerated by acute hypotension: Arterial and venous contribution to leukoaraiosis. PMID: 28202707

Wang et al. (2017) J Neurosci. 37(11):2870-2877. Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts. PMID: 28188218

February 2017

Benveniste et al. (2017) J Clin Invest. 127(2):447-449. Seeing how we smell. PMID: 28112677

Cotrina et al. (2017) Neuroscience 343:483-494. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. PMID: 28003156

Chappell et al. (2017) Trials 18(1):78. Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study. PMID: 28222778

Mair et al. (2017) Stroke. 48(2):353-360. Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke. PMID: 28008093

Muñoz Maniega et al. (2017) J Cereb Blood Flow Metab 37(2):644-656 Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease. PMID: 26933133

Van der Putten et al. (2017) Physiol Meas. 38(2):205-218. A multispectral microscope for in vivo oximetry of rat dorsal spinal cord vasculature. PMID: 28001129

January 2017

Benveniste et al. (2017) Neuroscientist. The Glymphatic Pathway. PMID: 28466758

Blair et al. (2017) Int J Stroke. Preventing cognitive decline and dementia from cerebral small vessel disease: the laci-1 trial. Protocol and statistical analysis plan f a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination. PMID: 28906205

Boulos et al. (2017) J Stroke Cerebrovasc Dis. 26(1):143-149. Unattended Hospital and Home Sleep Apnea Testing Following Cerebrovascular Events. PMID: 27717683

Dickie et al. (2017) Int J Stroke. Blood pressure variability and leukoaraiosis in acute ischemic stroke. PMID: 28872448

Job et al. (2017) Neuroimage. 144(PtB):299-304. A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS). PMID: 26794641

Liu et al.,(2017) J Cereb Blood Flow Metab. Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. PMID: 29192539

Loos et al. (2017) Int J Stroke. The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke. PMID: 28906203

Pinter et al. (2017) Sci Rep. Impact of small vessel disease in the brain on gait and balance. PMID: 28134332

Rungta et al. (2017) Nat Commun. Light controls cerebral blood flow in naive animals. PMID: 28139643

Swardfager et al. (2017) Alzheimers Dement 7:56-60. Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report. PMID: 28275700

Thrippleton et al. (2017) Int J Stroke. Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing. PMID: 28933655