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Publications from network members since the project began

February 2018

Montagne et al. (2018) Nat Med Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. PMID: 29400711

Ballerini et al. (2018) Sci Rep. 8(1):2132. Perivascular spaces segmentation in brain MRI using optimal 3D filtering. PMID: 29391404

January 2018

Pinter et al. (2018) Aging 10(1):144-153. Predictors of gait speed and its change over three years in community-dwelling older people. PMID: 29356686

November 2017

Swardfager et al. (2017) Neurobiol Aging. Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease. PMID: 28756941

October 2017

Patel et al. (2017) Neurol Res. 39(10):910-917. Chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis causes selective recognition impairment in adult mice. PMID: 28828966

September 2017

Amar et al. (2017) Neuropharmacology. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. PMID: 28923278

Benveniste et al. (2017) Anaesthesiology. Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compare with High-dose Isoflurane. PMID: 28938276

Bowles et al. (2017) Neuroimage. Brain lesion segmentation through image synthesis and outlier detection. 

Danso et al. (2017) MAPPING: MAnagement and Processing of Images for Population ImagiNG (Fronteirs eBook). Developing an Integrated Image Bank and Metadata for Large-scale Research in Cerebrovascular Disease: Our Experience from the Stroke Image Bank Project. Download here

Dickie et al. (2017) MAPPING: MAnagement and Processing of Images for Population ImagiNG (Fronteirs eBook). 5 Whole Brain Magnetic Resonance Image Atlases: A Systematic Review of Existing Atlases and Caveats for Use in Population Imaging. Download here

Loveau et al. (2017) J Clin Invest 127(9):3210-3219. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. PMID: 28862640 

Makin et al. (2017) J Stroke Cerebrovasc Dis. Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review. PMID: 28889932

Makin et al. (2017) European Stroke Journal. The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke. 

Mutsaerts et al. (2017) J Cereb Blood Flow Metab. 37(9):3184-3192. The spatial coefficient of variation in arterial spin labeling cerebral blood flow images. PMID: 28058975

Wardlaw et al. (2017) Neurology 89(10):1003-1010. White matter hyperintensity reduction and outcomes after minor stroke. PMID: 28794252

August 2017

Mestre et al. (2017) Clin Sci 131(17):2257-2274 Perivascular spaces, glymphatic dysfunction, and small vessel disease. PMID: 28798076

Nelson et al. (2017) Proc Natl Acad Sci USA. 114(33):8681-8682. Role of clusterin in the brain vascular clearance of amyloid-ß. PMID: 28765369

Wardlaw et al. (2017) J Cereb Blood Flow Metab 37(8):3042-3052 Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study. PMID: 28155579

Valdes Hernandez et al. (2017) Neuroradiology. Metric to quantify white matter damage on brain magnetic resonance images. PMID: 28815362

July 2017

McHutchison et al. (2017) Epidemiology 28(4):608-618. Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life: A Meta-analysis. PMID: 28410350   A video explaining this research can be accessed here

Swardfager et al. (2017) Neurobiol Aging. Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease. PMID: 28756941

van Veluw et al. (2017) Lancet Neurology. Detection, risk factors and functional consequences of cerebral microinfarcts. PMID: 28716371

Shirzadi et al. (2017) J Magn Reson Imaging. Enhancement of automated blood flow estimates (ENABLE) from arterial spin-labeled MRI. PMID: 28681479

Nestor et al. (2017) Alzheimers Dement 13(7):749-760. Small vessel disease is linked to disrupted structural network covariance in Alzheimer's disease. PMID: 28137552

Zhao and Zlokovic (2017) Cell. Res. 27(7):849-850. Remote control of BBB: A tale of exosomes and microRNA. PMID: 28674430

Kisler et al. (2017) Nat Rev Neurosci. 18(7):419-434. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. PMID: 28515434

Valdés Hernández et al. (2017) Front. Neurol. Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity. Access here

Blair et al. (2017) Current Treatment Options in Cardiovascular Medicine 19(7):56. Advanced Neuroimaging of Cerebral Small Vessel Disease. PMID: 28620783

McHutchison et al. (2017). Epidemiology 28(4):608-618. Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life: A Meta-analysis. PMID: 28410350

Cameron et al. (2017) Prog Retin Eye Res 59:131-157. Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease. PMID: 28457789

Arba et al. (2017) Journal of Stroke and Cerebrovascular Diseases 26(7):1506-1513. Cerebral White Matter Hypoperfusion Increases with Small Vessel Disease Burden. Data from the Third International Stroke Trial. PMID: 28314624

June 2017

Lee et al. (2017) Magn Reson Med. Quantative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. PMID: 28627037

Lundgaard et al. (2017) J Cereb Blood Flow Metab 37(6):2112-2124. Glymphatic clearance controls state-dependent changes in brain lactate concentration. PMID: 27481936

Robertson et al. (2017) AJNR Am J Neuroradiol. Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity. PMID: 28619834

Kjaerby et al. (2017) Neurochem Res. 42(6):1810-1822. Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function? PMID: 28210958

Wardlaw et al. (2017) Alzheimer's and Dementia 13(6):634-643. Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study. Access here

Shenkin et al. (2017) Neuroimage 153:399-409. Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group. PMID: 28232121

González-Castro et al. (2017) Clin Sci 131(13):1465-1481. reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance PMID: 28468952

May 2017

Ratner et al. (2017) Neuroimage 152:530-537. Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport. PMID: 28323163

Wiseman et al. (2017) Lupus 26(6):588-597. Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study and meta-analysis. PMID: 27687026

Mutsaerts et al. (2017) J Magn reson Imaging. Comparison of arterial spin labeling registration strategies in the multi-centre GENetic frontotemporal dementia initiative (GENFI). PMID: 28480617

April 2017

Nikolakopoulou et al. (2017) PLoS One Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signalling. PMID: 28441414

Joutel and Chabriat (2017) Clin Sci. 131(8):635-651. Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms. PMID: 28351960

Keith et al. (2017) J Neuropathol Exp Neurol. 76(4):299-312. Collagenosis of the Deep Medullary Veins: An Underrecognised Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction? PMID: 28431180

Cox et al. (2017) Psychoneuroendocrinology 78:151-158. Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men. PMID: 28199858

March 2017

Kisler et al. (2017) Nat Neurosci. 20(3):406-416. Pericyte degeneration leads to neurovascular uncoupling and limites oxygen supply to brain. PMID: 28135240

de Leon et al. (2017) J Nucl Med. CSF clearance in Alzheimer Disease measured with dynamic PET. PMID: 28302766

Pettersen et al. (2017) Neurology 88(11):1077-1080. CADASIL accelerated by acute hypotension: Arterial and venous contribution to leukoaraiosis. PMID: 28202707

Wang et al. (2017) J Neurosci. 37(11):2870-2877. Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts. PMID: 28188218

Backhouse et al. (2017) Neurology. 88(10):976-984 Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis. PMID: 28188307

February 2017

Cotrina et al. (2017) Neuroscience 343:483-494. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. PMID: 28003156

Chappell et al. (2017) Trials 18(1):78. Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study. PMID: 28222778

Muñoz Maniega et al. (2017) J Cereb Blood Flow Metab 37(2):644-656 Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease. PMID: 26933133

January 2017

Thrippleton et al. (2017) Int J Stroke. Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing. PMID: 28933655

Dickie et al. (2017) Int J Stroke. Blood pressure variability and leukoaraiosis in acute ischemic stroke. PMID: 28872448

Rungta et al. (2017) Nat Commun. Light controls cerebral blood flow in naive animals. PMID: 28139643

Blair et al. (2017) Int J Stroke. Preventing cognitive decline and dementia from cerebral small vessel disease: the laci-1 trial. Protocol and statistical analysis plan f a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination. PMID: 28906205

Benveniste et al. (2017) Neuroscientist. The Glymphatic Pathway. PMID: 28466758

Pinter et al. (2017) Sci Rep. Impact of small vessel disease in the brain on gait and balance. PMID: 28134332

Loos et al. (2017) Int J Stroke. The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke. PMID: 28906203

Swardfager et al. (2017) Alzheimers Dement 7:56-60. Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report. PMID: 28275700