Our clinical aims are to test the following hypotheses:
- PVS morphology correlates with biomarkers of cerebrovascular dysfunction
- Vascular risk factors and sleep apnoea severity correlate with PVS structure and cerebrovascular function
- Treatment of sleep apnoea improves PVS structure and cerebrovascular function
We will develop computational methods for characterisation of enlarged PVS. Our combined expertise in advanced MRI imaging will be used to measure blood brain barrier function, cerebrovascular reactivity and other measures of brain health, which will be tested for correlation with enlarged PVS.